- Jean-Louis Vincent, Erasme University Hospital
Nuclear-encoded mitochondrial genes are differentially expressed early in pediatric septic shock compared with healthy controls, indicating the nuclear genome may be an important mechanism contributing to alterations in mitochondrial bioenergetic function and outcomes in pediatric sepsis.
High quality research to determine the accuracy of delirium screening tools in the pediatric intensive care unit (PICU) are required before prevalence, risk factors, treatment, and outcomes can be determined.
Inter-hospital transfer of critically ill patients with acute kidney injury (AKI) does not increase risk of death or dialysis dependence 30 days after the initiation of acute renal replacement therapy.
New prognostic factors have been included into the updated Revised Injury Severity Classification (RISC) score, which outperforms the previous RISC model in discrimination, precision and calibration.
TLR4-mediated inflammation may be an important part of the pathogenesis underlying gram-negative septic acute kidney injury; treatment with a TLR4-inhibitor is able to reverse this impairment of renal function.
HIV infection is related to a higher frequency of severe sepsis and death among patients admitted to the ICU; coinfection with Hepatitis C virus increases risk of death in the presence and absence of sepsis.
Aims & scope
Critical Care is a high quality, peer-reviewed, international open access clinical medical journal. Critical Care aims to improve the care of critically ill patients by acquiring, discussing, distributing, and promoting evidence-based information relevant to intensivists.
The journal publishes commentaries, reviews, and research in all areas of intensive care and emergency medicine. Critical Care aims to provide a comprehensive overview of the intensive care field.
All reviews, commentaries and reports published in Critical Care become free to access 12 months after publication. See below for the latest free review.
Fernando Souza-Fonseca-Guimaraes, Jean-Marc Cavaillon, Minou Adib-ConquyCritical Care 2013, 17:235 (27 August 2013)
- 19 November 2014
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- 07 November 2014
- Clotting factors similar in reversing vtamin K antagonist