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Evidence-Based Medicine Journal Club

Each month the University of Pittsburgh Department of Critical Care Medicine (CCM) convenes a multidisciplinary evidence-based medicine journal club, a mandatory component of CCM training at the University of Pittsburgh. The purpose of journal club is to provide critical appraisals of articles that impact the clinical practice of critical care and to foster the development of skills necessary for the practice of evidence-based medicine. With the guidance of a faculty mentor, fellows in the University of Pittsburgh critical care training programme lead the discussion of an article, which is chosen based on the following criteria:

  1. The article must have been published in the past two years and not previously discussed in the journal club.
  2. The study must contain no major flaws of methodology.
  3. The results of the study, if valid, must impact clinical practice in some way.

After the fellow's presentation, the article is then open for debate with the overall tone of truly trying to understand the implications of the study. A point is always made to answer the question "Based on the results of this study, should we change clinical practice?"

After the debate, the fellow and faculty mentor prepare a written record of the proceedings in the form of an expanded abstract with a three to four paragraph commentary. These proceedings, previously available only to members of the Department, will now be available online in Critical Care. In making these available to the online critical care community, we hope to enrich the consideration of current literature while also providing an evidence-based opinion of whether each study should change clinical practice.



Editorial
Evidence-based medicine journal club
Eric B Milbrandt, Jean-Louis Vincent
Critical Care 2004, 8:401-402 (3 November 2004)
[Abstract] [Full text] [PDF] [PubMed] [Related articles] [Cited on BioMed Central]

Journal club critique

All journal club critiques are free to access.

Journal club critique    
NGAL: an emerging tool for predicting severity of AKI is easily detected by a clinical assay
Wes Gabbard, Eric B Milbrandt, John A Kellum
Critical Care 2010, 14:318 (23 August 2010)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
Clearing up the confusion: The results of two pilot studies of antipsychotics for ICU delirium
Zaher Qassem, Eric B Milbrandt
Critical Care 2010, 14:316 (11 August 2010)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
Dirty mouth? Should you clean it out? Decontamination for the prevention of pneumonia and mortality in the ICU
Adeel B Shibli, Eric B Milbrandt, Marie Baldisseri
Critical Care 2010, 14:314 (18 June 2010)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
To JUPITER and beyond: Statins, inflammation, and primary prevention
Ajay D Rao, Eric B Milbrandt
Critical Care 2010, 14:310 (13 May 2010)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
Epinephrine: Is it really the black sheep of vasoactive agents?
Ritwick Agrawal, Ali Al-Khafaji, Sachin Yende
Critical Care 2010, 14:309 (13 May 2010)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
Ave, CESAR, morituri te salutant! (Hail, CESAR, those who are about to die salute you!)
David J Wallace, Eric B Milbrandt, Arthur Boujoukos
Critical Care 2010, 14:308 (26 April 2010)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
Is albumin use SAFE in patients with traumatic brain injury?
Christopher R Brackney, Luis A Diaz, Eric B Milbrandt, Ali Al-Khafaji, Joseph M Darby
Critical Care 2010, 14:307 (9 April 2010)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
Intensivists: don't quit your day job...yet!
Gregory A Watson, Louis H Alarcon
Critical Care 2010, 14:305 (7 April 2010)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
Thrombolysis during out-of-hospital cardiac arrest: a lesson in the law of diminishing returns
James M Dargin, Lillian L Emlet
Critical Care 2010, 14:304 (22 March 2010)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
The role of noninvasive ventilation in acute cardiogenic pulmonary edema
Ashar Salman, Eric B Milbrandt, Michael R Pinsky
Critical Care 2010, 14:303 (12 March 2010)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
Are specialized ICUs so special?
Yên-Lan C Nguyen, Eric B Milbrandt
Critical Care 2009, 13:314 (12 October 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
CORTICUS: The end of unconditional love for steroid use?
Phillip E Mason, Ali Al-Khafaji, Eric B Milbrandt, Brian P Suffoletto, David T Huang
Critical Care 2009, 13:309 (7 August 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
Immunonutrition in critical illness: still fishing for the truth
Adam Peterik, Eric B Milbrandt, Joseph M Darby
Critical Care 2009, 13:305 (12 June 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
Diagnostic techniques for ventilator-associated pneumonia: Conflicting results from two trials
Younghoon Kwon, Eric B Milbrandt, Sachin Yende
Critical Care 2009, 13:303 (14 May 2009)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
Procalcitonin-guided antibiotics in severe sepsis
Peter Simon, Eric B Milbrandt, Lillian L Emlet
Critical Care 2008, 12:309 (4 December 2008)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
Black Hawk Down: The evolution of resuscitation strategies in massive traumatic hemorrhage
Deepika Mohan, Eric B Milbrandt, Louis H Alarcon
Critical Care 2008, 12:305 (23 July 2008)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
Rethinking bystander CPR for out-of-hospital cardiac arrest
Scott A Crane, Clifton W Callaway, Eric B Milbrandt, David T Huang
Critical Care 2008, 12:302 (12 March 2008)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

Journal club critique    
PAC in FACTT: Time to PAC it in?
Wissam Mansour, Eric B Milbrandt, Lillian L Emlet
Critical Care 2008, 12:301 (6 February 2008)
[Abstract] [Full text] [PDF] [PubMed] [Related articles] [Cited on BioMed Central]

Journal club critique    
Albumin and furosemide for acute lung injury
Asjad Khan, Eric B Milbrandt, Ramesh Venkataraman
Critical Care 2007, 11:314 (27 September 2007)
[Abstract] [Full text] [PDF] [PubMed] [Related articles] [1 comment]

Journal club critique    
Continuous vs. intermittent hemodialysis: with which spin will my patient win?
Kamal Chater, John A Kellum
Critical Care 2007, 11:313 (27 September 2007)
[Abstract] [Full text] [PDF] [PubMed] [Related articles]

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