Table 3

Evidence for loop diuretic therapy in acute tubular necrosis (ATN)

Indication (result)
Strength of
Source

evidence


Radiocontrast ATN


     For prevention (no)
Level I
Solomon et al [3]




Ischemic ATN


     For prevention (?)
No data in humans

     Vascular surgery (no)
Level I*
Hager et al [8]




Treatment of ATN


     Rhabdomyolysis (no)
Level IV
Better et al [7]
     Improves outcome (no)
Level II
Kleinknecht et al [11]

*Loop diuretics were begun after surgery and continued through the ICU stay.

Kellum Critical Care 1997 1:53   doi:10.1186/cc103

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