Molecular mechanism underlying the interaction between antithrombin and heparin. Signalling events triggered by antithrombin (AT) affect chemotaxis receptor function. Mediator release and adhesion molecule expression is altered by inhibiting the interaction of nuclear factor-κB (NF-κB) with CBP/p300 through cAMP-dependent protein kinase A-induced CREB activation . Exogenous unfractionated heparin or low-molecular-weight heparin (LMWH) may prevent AT from interacting with heparin sulfate proteoglycans (HSPGs) by competitive ligand binding at the heparin binding site of AT. PK, protein kinase; RANTES, regulated upon activation, normal T-cell expressed and secreted.
Wiedermann Critical Care 2006 10:209 doi:10.1186/cc4822