Use of prophylactic fluconazole in a neonatal intensive care unit: efficacy is similar to that described in adult high-risk surgical patients
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* Corresponding author: Paolo Manzoni paolomanzoni@hotmail.com
Neonatology and Hospital NICU, Azienda Ospedaliera Regina Margherita, Turin, Italy
Critical Care 2006, 10:402 doi:10.1186/cc3958
Published: 5 January 2006First paragraph (this article has no abstract)
We read with great interest the recent article by Ho and coworkers [1] concerning the use of prophylactic fluconazole in high-risk surgical patients, in which those authors reported on seven randomized controlled studies from the Cochrane Controlled Trial Register. Ho and colleagues concluded that the use of prophylactic fluconazole in immunocompetent high-risk surgical patients is associated with a reduced incidence of candidaemia, fewer patients requiring systemic amphotericin B as rescue therapy for systemic fungal infection, and no increase in the proportion of patients colonized with or infected with fluconazole-resistant fungi, but with only a trend toward a reduction in hospital mortality.