Table 2 |
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|
Acid–base and electrolyte data |
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|
Acid–base and electrolyte data |
Baseline |
t = 24 |
|
|
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|
PH |
7.49 (7.48–7.51) |
7.46 (7.44–7.48) |
|
PaCO2 (kPa) |
5.7 (5.1–6.1) |
5.3 (4.9–5.9) |
|
Bicarbonate (mmol/l) |
31.5 (29.5–33.7) |
28.6 (26.3–30.3) |
|
Sodium (mmol/l) |
141 (139–145) |
142 (139–145) |
|
Potassium (mmol/l) |
3.7 (3.7–4) |
3.8 (3.4–3.9) |
|
Chloride (mmol/l) |
106 (102–107) |
108 (107–110) |
|
Creatinine (μmol/l) |
64 (49–95) |
65 (49–101) |
|
Lactate (mmol/l) |
1.4 (1.2–1.8) |
1.5 (1.2–1.7) |
|
Albumin (g/l) |
16 (14–20) |
17 (15–20) |
|
Apparent SID (mEq/l) |
41.7 (39.1–44.0) |
39.4 (36.4–41.4) |
|
Effective SID (mEq/l) |
39.0 (37.3–40.3) |
35.6 (32.9–37.7) |
|
SIG (mEq/l) |
2.4 (1.5–4.4) |
3.1 (2.1–4.8) |
|
Sodium–chloride effect (mEq/l) |
-2.0 (-3.5 to +0.5) |
-3.0 (-7.5 to -1.5) |
|
|
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Shown are baseline acid–base and electrolyte data (median [interquartile range]) for 15 patients before administration of 500 mg acetazolamide (baseline) and after 24 hours (t = 24). The serum apparent SID (SIDapp) was calculated using the following equation: SIDapp = [Na+] + [K+] + [Ca2+] + [Mg2+] - [Cl-] - [lactate-]. The serum effective SID (SIDeff) was calculated using the following equation: SIDeff = 12.2 × PCO2/(10-pH) + [albumin] × (0.123 × pH - 0.631) + [PO4-] × (0.309 × pH - 0.469). The SIG was calculated using the following equation: SIG = SIDapp - SIDeff. The sodium–chloride effect was calculated using the formula [Na+] - [Cl-] - 38. PaCO2, arterial carbon dioxide tension; SID, strong ion difference; SIG, strong ion gap. |
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Moviat et al. Critical Care 2006 10:R14 doi:10.1186/cc3970 |
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