Table 2

Effects of epinephrine and dopexamine–norepinephrine on hemodynamics, oxygenation parameters and gastric mucosal blood flow

Parameter

Group

T₀

T₁

T₂

T₃

p (time effect)

p (treatment effect)

p (interaction)

MAP, mmHg

E

52 ± 7

81 ± 5

78 ± 4

87 ± 13

0.225

0.232

0.224

D–N

56 ± 8

79 ± 8

80 ± 9

80 ± 13

RAP, mmHg

E

11 ± 3

13 ± 3

12 ± 3

10 ± 3

0.028

0.597

0.987

D–N

12 ± 3

13 ± 5

12 ± 3

10 ± 4

MPAP, mmHg

E

23 ± 3

29 ± 6

29 ± 4

27 ± 5

0.289

0.141

0.453

D–N

27 ± 6

31 ± 8

28 ± 6

27 ± 7

PCWP, mmHg

E

14 ± 4

15 ± 3

15 ± 4

14 ± 3

0.201

0.268

0.342

D–N

15 ± 4

16 ± 6

14 ± 4

12 ± 4

HR, beats/min

E

94 ± 18

114 ± 24

113 ± 12

115 ± 14

0.991

0.023

0.699

D–N

102 ± 17

108 ± 21

109 ± 19

109 ± 18

SV, ml

E

68 ± 30

92 ± 39

87 ± 36

81 ± 33

0.032

0.531

0.334

D–N

67 ± 21

81 ± 26

81 ± 18

78 ± 21

CO, l/min

E

6.2 ± 2.4

10.1 ± 3.8

9.8 ± 4.1

9.2 ± 3.4

0.115

0.039

0.454

D–N

6.8 ± 2.2

8.6 ± 2.7

8.8 ± 2.1

8.4 ± 2.6

SVR, dyne.s/cm⁵

E

588 ± 188

635 ± 335

666 ± 400

803 ± 438

0.006

0.743

0.141

D–N

621 ± 412

722 ± 417

672 ± 275

746 ± 353

PVR, dyne.s/cm⁵

E

142 ± 84

122 ± 78

145 ± 103

143 ± 111

0.126

0.419

0.295

D–N

198 ± 207

175 ± 166

128 ± 40

164 ± 77

DO₂, ml/min

E

624 ± 246

1,142 ± 442

1,160 ± 518

1,163 ± 415

0.500

0.009

0.918

D–N

701 ± 220

967 ± 306

1,021 ± 275

968 ± 318

VO₂, ml/min

E

180 ± 46

275 ± 89

286 ± 53

250 ± 81

0.533

0.001

0.527

D–N

204 ± 60

178 ± 78

206 ± 95

219 ± 108

GMBF, pu

E

76 (61–107)

91 (62–136)

90 (72–133)

125 (90–160)

0.084

0.048

0.913

D–N

106 (93–157)

137 (99–198)

133 (114–158)

165 (124–190)

GMBF/CO, pu l^-1 min^-1

E

18 (9–20)

11 (7–17)

15 (6–17)

15 (11–18)

0.128

0.015

0.686

D–N

15 (10–20)

17 (11–25)

15 (10–23)

18 (11–39)

Data are presented as means ± SD for normally distributed variables and as medians (25th to 75th centiles) for non-normally distributed variables. p values are those given by a two-way (time, treatment) analysis of covariance, the analysis being adjusted on baseline values (mixed model) for normally distributed variables or a non-parametric repeated-measures analysis, and also adjusted on baseline values (mixed model), performed on ranked data, for non-normally distributed variables. CO, cardiac output; D, dopexamine; DO₂, oxygen delivery; E, epinephrine; GMBF, gastric mucosal blood flow; HR, heart rate; MAP, mean arterial pressure; MPAP, mean pulmonary arterial pressure; N, norepinephrine; PCWP, pulmonary capillary wedge pressure; pu, perfusion units; PVR, pulmonary vascular resistances; RAP, right atrial pressure; SV, stroke volume; SVR, systemic vascular resistances; VO₂, oxygen consumption.

Seguin et al. Critical Care 2006 10:R32   doi:10.1186/cc4827