Early venovenous haemodiafiltration for sepsis-related multiple organ failure

doi:10.1186/cc4906

Critical Care
Volume 10
Issue 2

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Letter

Early venovenous haemodiafiltration for sepsis-related multiple organ failure

Frédéric M Jacobs and François G Brivet

Service de Réanimation Médiacle, Hôpital Antoine Béclère-Assistance, Publique Hôpitaux de Paris, Paris, France

author email corresponding author email

Critical Care 2006, 10:409doi:10.1186/cc4906


Published:	28 April 2006

See related research by Page et al., http://ccforum.com/content/9/6/R755

First paragraph (this article has no abstract)

In a prospective observational study that included 60 consecutive patients over a 10-year period, Page and coworkers [1] studied the effects of early continuous veno-venous haemodiafiltration (CVVHDF) during sepsis-induced multiple organ failure. In two-thirds of the patients rapid metabolic improvement during CVVHDF was associated with circulatory improvement and a low mortality rate, whereas lack of metabolic improvement after 12 hours of CVVHDF (mainly based on changes in base excess) was associated with a 100% mortality rate. The authors concluded that early CVVHDF may improve the prognosis of sepsis-related multiple organ failure, and that failure to correct metabolic acidosis rapidly during the procedure is a strong predictor of mortality.