Table 1

Changes in haemodynamic variables, acid-base status, reactive hyperaemia, and vasomotion

Parameters

Group

Baseline

1 hour

P

MAP (mmHg)

AVP/NE*

64 ± 5

81 ± 12

0.047^†

NE

64 ± 9

66 ± 13

CI (l/min per m²)

AVP/NE

4.1 ± 1.2

3.8 ± 1.1

0.152

NE

3.5 ± 0.9

3.5 ± 0.8

DO₂I (ml/min/m²)

AVP/NE

571 ± 140

526 ± 130

0.151

NE

482 ± 111

493 ± 119

VO₂I (mL/min/m²)

AVP/NE

155 ± 39

157 ± 35

0.077

NE

131 ± 35

137 ± 41

SvO₂ (%)

AVP/NE

72 ± 6

66 ± 13

0.583

NE

71 ± 9

70 ± 10

NE requirements (μg/kg per min)

AVP/NE*

0.75 ± 0.31

0.51 ± 0.19

0.36

NE

0.65 ± 0.23

0.76 ± 0.18

Milrinone requirements (μg/kg per min)

AVP/NE

0.44 ± 0.15

0.44 ± 0.16

0.025^†

NE

0.31 ± 0.2

0.29 ± 0.19

pH

AVP/NE

7.30 ± 0.12

7.30 ± 0.12

0.355

NE

7.33 ± 0.1

7.32 ± 0.08

Lactate (mmol/l)

AVP/NE

5.9 ± 6.7

6.6 ± 6.3

0.548

NE

7.6 ± 6.1

7.5 ± 5.6

AUC pre-ischaemic

AVP/NE

21.2 ± 9.4

16.7 ± 7.7

0.089

NE

15.3 ± 10.2

15.3 ± 9.0

Magnitude of RH (%)

AVP/NE

64 ± 57.2

70 ± 47.5

0.56

NE

49.4 ± 24.8

48.7 ± 41.7

ODS pre-ischaemic (oscillations/min)

AVP/NE^‡

15.73 ± 5.15

14.38 ± 7.31

0.055^§

NE

7.49 ± 3.2

10.7 ± 3.81

ODS reperfusion (oscillations/min)

AVP/NE^‡

14.38 ± 4.85

13.78 ± 9.17

0.601^§

NE

8.99 ± 3.92

10.7 ± 5.7

Data are expressed as mean values ± standard deviation. AUC, area under the curve; AVP, arginine vasopressin; CI, cardiac index; DO₂I, systemic oxygen transport index; MAP, mean arterial pressure; NE, norepinephrine; ODS, oscillation of the Doppler signal; RH, reactive hyperaemia; SvO₂, mixed venous oxygen saturation; VO₂I, systemic oxygen consumption index. *significant difference over time; ^†, significant difference between groups; ^‡, significant difference at baseline between groups; ^§, corrected for baseline differences.

Luckner et al. Critical Care 2006 10:R40   doi:10.1186/cc4845