Table 3

Changes in markers of organ dysfunction for admissions with severe sepsis during the first 24 hours following admission to critical care, 1996 to 2004

Lowest systolic blood pressure (mmHg)

Hourly urine output (ml)

Lowest PaO2/FiO2 (kPa)

Lowest platelet count (× 109l-1)

Lowest pH

Highest base deficit


1996

85 (78–100)

75 (45–114)

20.0 (12.9–28.9)

170 (104–250)

7.28 (7.19–7.35)

5.1 (1.2–9.7)

1997

86 (75–100)

76 (45–114)

19.7 (12.8–28.6)

175 (106–253)

7.28 (7.19–7.35)

5.0 (1.1–9.5)

1998

87 (75–100)

74 (43–109)

19.7 (13.0–28.3)

171 (106–249)

7.28 (7.19–7.35)

4.8 (0.8–9.3)

1999

90 (77–100)

73 (43–109)

19.9 (12.9–28.9)

177 (109–256)

7.28 (7.18–7.35)

4.9 (0.6–9.4)

2000

90 (78–100)

70 (42–106)

19.3 (12.5–28.0)

184 (110–268)

7.28 (7.19–7.36)

4.7 (0.5–9.2)

2001

90 (79–100)

68 (40–103)

20.0 (12.9–28.8)

197 (122–284)

7.28 (7.18–7.35)

4.9 (0.7–9.5)

2002

90 (80–100)

69 (41–104)

19.7 (12.8–29.0)

202 (126–291)

7.28 (7.18–7.35)

4.9 (0.8–9.3)

2003

90 (79–100)

66 (39–101)

19.8 (12.7–28.8)

199 (124–287)

7.28 (7.18–7.35)

5.1 (1.1–9.5)

2004

90 (79–100)

63 (36–98)

19.8 (13.1–29.2)

199 (124–287)

7.27 (7.18–7.35)

4.7 (0.7–9.0)


Totala

90 (78–100)

69 (41–105)

19.8 (12.8–28.7)

189 (116–274)

7.27 (7.18–7.35)

4.9 (0.8–9.4)


Values are median (interquartile range) of the most extreme physiological measurement from the first 24 hours following admission to critical care. aTotal includes 55 admissions from 1995 and 78 admissions from 2005. FiO2, fraction of inspired oxygen; PaO2, arterial partial pressure of oxygen.

Harrison et al. Critical Care 2006 10:R42   doi:10.1186/cc4854

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