Table 6

Sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio and negative likelihood ratio of inflammatory markers in diagnosing infection
Variable
 Cut-off level
 Sensitivity (%)
 Specificity (%)
 Positive predictive value (%)
 Negative predictive value (%)
 Positive likelihood ratio
 Negative likelihood ratio
Procalcitonin
 0.075 ng/ml
 80.2
 47.8
 70.8
 60.4
 1.5
 0.41

0.1 ng/ml
 71.6
 62.7
 75.3
 58.3
 1.9
 0.45

0.25 ng/ml
 48.1
 89.5
 87.9
 52.2
 4.6
 0.58

0.5 ng/ml
 37.7
 95.5
 93.0
 49.2
 8.4
 0.65
Lipopolysaccharide-binding protein
 20 μg/ml
 78.3
 64.2
 77.6
 65.2
 2.2
 0.34

40 μg/ml
 37.7
 91.0
 86.9
 48.0
 4.2
 0.68
C-reactive protein
 30 mg/l
 80.2
 62.7
 77.3
 66.7
 2.2
 0.32

50 mg/l
 73.6
 74.6
 82.1
 64.1
 2.9
 0.35

100 mg/l
 62.3
 89.5
 90.4
 60.0
 5.9
 0.42
IL-6
 16.3 pg/ml
 79.2
 64.2
 77.8
 66.2
 2.2
 0.32

25 pg/ml
 70.8
 77.6
 83.3
 62.6
 3.2
 0.38

50 pg/ml
 58.5
 88.0
 88.6
 57.3
 4.9
 0.47

Gaïni et al. Critical Care 2006 10:R53   doi:10.1186/cc4866