Table 2

Regional metabolic and oxygen-derived variables in both groups

Bacterial infusion

Fluid resuscitation

Follow up

T0

T30

T60

T90

T120

T150

T180

T210

mDO₂ (ml/minute)

LR

103 ± 11

42 ± 4^a

83 ± 10

86 ± 12

57 ± 8^a

50 ± 6^a

43 ± 6^a

38 ± 5^a

HS

86 ± 3

50 ± 3^a

85 ± 13

69 ± 10

62 ± 9^a

60 ± 9^a

63 ± 9^a

60 ± 8^a

mVO₂ (ml/minute)

LR

15.0 ± 2.3

11.3 ± 1.9

20.4 ± 2.5

19.7 ± 2.6

13.3 ± 2.7

15.9 ± 2.1

15.3 ± 2.1

10.5 ± 1.5

HS

14.8 ± 2.4

11.6 ± 1.5

13.1 ± 1.7

10.9 ± 1.6

11.5 ± 1.4

11.2 ± 1.2

12.6 ± 1.76

12.1 ± 2.1

mO₂ER (%)

LR

11.2 ± 2.5

25.3 ± 5.1

22.8 ± 2.4^a

24.7 ± 3.4^a

32.64 ± 6.0^a

38.0 ± 5.8^a,b

39.9 ± 5.3^a,b

36.5 ± 5.4^a,b

HS

13.2 ± 1.7

22.8 ± 3.4^a

18.8 ± 3.4

17.7 ± 2.7

20.3 ± 2.3^a

19.8 ± 2.0

21.9 ± 2.2

18.5 ± 1.9

PgCO₂ (mmHg)

LR

42.1 ± 1.7

51.4 ± 3.8^a

60.2 ± 5.3^a

72.2 ± 8.1^a

75.2 ± 7.3^a

77.0 ± 1.8^a

84.8 ± 7.1^a

89.7 ± 7.5^a

HS

39.8 ± 1.6

45.1 ± 2.0^a

53.5 ± 3.2^a

56.0 ± 3.3^a

62.8 ± 2.9^a

68.8 ± 3.1^a

75.5 ± 4.0^a

80.6 ± 4.1^a

PL (mmol/l)

LR

0.97 ± 0.3

1.73 ± 0.4^a

2.48 ± 0.4^a

3.70 ± 0.5^a

3.65 ± 0.4^a

4.14 ± 0.6^a

5.21 ± 1.0^a

4.70 ± 0.9^a

HS

1.42 ± 0.2

1.98 ± 0.3^a

2.81 ± 0.31^a

4.24 ± 0.2^a

4.88 ± 0.3^a

4.52 ± 0.2^a

4.61 ± 0.2^a

4.52 ± 0.2^a

Bacterial infusion: intravenous infusion of 1.2 × 10¹⁰ cfu/kg of live Escherichia coli in 30 minutes in both groups. Fluid resuscitation: LR group received lactated Ringer's solution 32 ml/kg over 30 minutes, n = 7; HS group received 7.5% hypertonic saline solution 4 ml/kg over 5 minutes, n = 8. Follow up: 120 minutes without additional interventions. mDO₂, mesenteric oxygen delivery; mVO₂, mesenteric oxygen consumption; mO₂ER, mesenteric oxygen extraction rate; PgCO₂, gastric mucosal pCO₂; PL, portal vein lactate. Data are expressed as mean ± standard error. ^ap < 0.05 versus T0, both groups; ^bp < 0.05, LR versus HS.

Garrido et al. Critical Care 2006 10:R62   doi:10.1186/cc4901