Figure 1.

Study overview: flow chart representing the patient flow throughout the different study visits. Visit 1, onset of study therapy; visit 2 (3–5 days later), investigators streamlined antibiotics if favourable microbiological data were available; visit 3, patients were re-evaluated after discontinuation of therapy, visit 4, patients were re-evaluated 7–9 days later. MITT, modified intention-to-treat; D, dead; LFU, lost to follow-up.