Critical Care

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Sedation in the intensive care unit with remifentanil/propofol versus midazolam/fentanyl: a randomised, open-label, pharmacoeconomic trial

Bernd Muellejans*, Thomas Matthey, Joachim Scholpp and Markus Schill

Critical Care 2006, 10:R91 doi:10.1186/cc4939

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The incidence of sub-optimal sedation in the ICU: a systematic review

Daniel L Jackson, Clare W Proudfoot, Kimberley F Cann, Tim S Walsh Critical Care 2009, 13:R204 (16 December 2009)

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Remifentanil discontinuation and subsequent intensive care unit-acquired infection: a cohort study

Saad Nseir, Jérémy Hoel, Guillaume Grailles, Aude Soury-Lavergne, Christophe Di Pompeo, Daniel Mathieu, Alain Durocher Critical Care 2009, 13:R60 (21 April 2009)

Remifentanil discontinuation is associated with an increased risk of ICU-acquired infection, an observation that reiterates previous reports on the negative effects of opioid withdrawal on the immune system.

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The place for short-acting opioids: special emphasis on remifentanil

Wolfram Wilhelm, Sascha Kreuer Critical Care 2008, 12(Suppl 3):S5 (14 May 2008)

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Changes in sedation management in German intensive care units between 2002 and 2006: a national follow-up survey

Jörg Martin, Martin Franck, Stefan Sigel, Manfred Weiss, Claudia Spies Critical Care 2007, 11:R124 (6 December 2007)