Figure 2.

PROWESS 28-day survival curves based on baseline and day 1 protein C activity levels. Baseline and day 1 protein C levels for patients by treatment group were assessed and 28-day outcomes determined. Kaplan-Meier survival curves of each group are presented. Curves were compared using the log-rank test and P < 0.05 was considered significant. Severely deficient (≤ 40%), moderately deficient (41–80%) and normal (>80%) baseline protein C categories are presented from left to right. (a) Survival curves of placebo patients. In all cases, if day 1 protein C levels improved (to >40%) or remained stable (no ≥ 10% decrease), survival was higher than if protein C levels remained ≤ 40% or decreased by ≥ 10%. The improvement was significant only for severely deficient and deficient patients.(b) Survival curves of PROWESS drotrecogin alfa (activated) (DrotAA) patients. A similar pattern was observed in DrotAA-treated patients as in placebo patients. In all cases, 28-day survival was higher if day 1 protein C levels improved (to >40%) or remained stable than if they remained ≤ 40% or decreased by ≥ 10%. The improvement was significant only for severely deficient and deficient patients.