Think outside the box: extrapulmonary manifestations of severe respiratory syncytial virus infection

doi:10.1186/cc5012

Critical Care

Volume 10
Issue 4

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Commentary

Think outside the box: extrapulmonary manifestations of severe respiratory syncytial virus infection

Kentigern Thorburn¹ and C Anthony Hart²

¹Department of Paediatric Intensive Care, Royal Liverpool Children's Hospital, Liverpool, UK

²Department of Medical Microbiology and Genito-urinary Medicine, University of Liverpool, UK

author email corresponding author email

Critical Care 2006, 10:159doi:10.1186/cc5012


Published:	24 August 2006

See related research by Eisenhut http://ccforum.com/content/10/4/R107

Abstract

Extrapulmonary effects of severe respiratory syncytial virus (RSV) infection are not uncommon. Dr Eisenhut's systematic review of extrapulmonary manifestations of severe RSV infection clearly demonstrates clinical consequences peripheral to the lung parenchyma. The extrapulmonary impact of RSV infection raises questions as to whether these are direct RSV effects (i.e., RSV infection of site-specific tissue), secondary to parenchymal lung disease and its causative respiratory failure, or the result of inflammatory mediators dispersed from the provoked respiratory epithelium.