Critical Care
Volume 10
Issue 4 |
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 ReviewCoagulation abnormalities in critically ill patientsMarcel Levi1  and Steven M Opal2  1Department of Vascular Medicine and Internal Medicine, Academic Medical Centre, University of Amsterdam, the Netherlands 2Infectious Disease Division, Brown Medical School, Providence, Rhode Island, USA  author email corresponding author email
Critical Care 2006,
10:222doi:10.1186/cc4975 Abstract
Many critically ill patients develop hemostatic abnormalities, ranging from isolated thrombocytopenia or prolonged global clotting tests to complex defects, such as disseminated intravascular coagulation. There are many causes for a deranged coagulation in critically ill patients and each of these underlying disorders may require specific therapeutic or supportive management. In recent years, new insights into the pathogenesis and clinical management of many coagulation defects in critically ill patients have been accumulated and this knowledge is helpful in determining the optimal diagnostic and therapeutic strategy. | 
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