|
|
|
| Test result |
Cause |
|
|
|
| PT prolonged, aPTT normal |
Factor VII deficiency |
| Mild vitamin K deficiency |
|
| Mild liver insufficiency |
|
| Low doses of vitamin K antagonists |
|
| PT normal, aPTT prolonged |
Factor VIII, IX, or XI deficiency |
| Use of unfractionated heparin |
|
| Inhibiting antibody and/or anti-phospholipid antibody |
|
| Factor XII or prekallikrein deficiency (no relevance for in vivo coagulation) |
|
| Both PT and aPTT prolonged |
Factor X, V, II or fibrinogen deficiency |
| Severe vitamin K deficiency |
|
| Use of vitamin K antagonists |
|
| Global clotting factor deficiency |
|
| Synthesis: liver failure |
|
| Loss: massive bleeding |
|
| Consumption: DIC |
|
|
aPTT, activated partial thromboplastin time; PT, prothrombin time. | |
Levi and Opal Critical Care 2006 10:222 doi:10.1186/cc4975 |
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