Bench-to-bedside review: Genetics and proteomics: deciphering gene association studies in critical illness

doi:10.1186/cc5015

Critical Care
Volume 10
Issue 4

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This article is part of a series on Translational Research, edited by Dr John Kellum.

Review

Bench-to-bedside review: Genetics and proteomics: deciphering gene association studies in critical illness

Sachin Yende¹ , Candace M Kammerer² and Derek C Angus¹

¹The CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illness) Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA

²Department of Human Genetics, University of Pittsburgh, PA, USA

author email corresponding author email

Critical Care 2006, 10:227doi:10.1186/cc5015


Published:	24 August 2006

Abstract

There is considerable interest in understanding genetic determinants of critical illness to improve current risk stratification models, provide individualized therapies, and improve our current understanding of disease mechanisms. This review provides a broad overview of genetic nomenclature, different study designs, and problems unique to each of these study designs in critical illnesses. Well designed genetic studies with careful attention to these issues during the planning phase, use of rigorous statistical methods during analysis, and replication of these results in different cohorts will lead to more robust results and improved understanding of genetics of critical care.