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Activated protein C in sepsis: down but not out, yet

Ritesh Agarwal* and Alok Nath

Author Affiliations

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India

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Critical Care 2006, 10:416 doi:10.1186/cc4988

Published: 26 July 2006

First paragraph (this article has no abstract)

We read with interest the recent commentary by Friedrich and coworkers [1], in which they consider whether the current evidence supports treatment for severe sepsis with drotrecogin alfa (activated). They conclude that the survival benefit is weak in patients with severe sepsis treated with activated protein C (APC) [1]. However, this conclusion has a number of limitations.