|
Acute illness characteristics including hospital care, intensive care and outcome for the study cohort |
|||
| Control group (n = 7,626) |
Corticosteroid exposure group (n = 2,632) |
P |
|
|
|
|||
| Hospital and intensive care |
|||
| Maximal daily Sequential Organ Failure Assessment |
3 (0–9) |
4 (1–11) |
0.0001 |
| Mechanical ventilation |
1,889 (25) |
765 (29) |
0.0001 |
| Mechanical ventilation ≥ 96 hours |
297 (4) |
372 (14) |
0.0001 |
| Tracheostomy |
124 (2) |
204 (8) |
0.0001 |
| Intensive care stay (days) |
1.2 (0.2–4.6) |
1.9 (0.3–9.6) |
0.0001 |
| Hospital stay (days) |
5.1 (1.3–12.4) |
6.8 (2.0–19.0) |
0.0001 |
| Corticosteroid exposure |
|||
| Hydrocortisone |
0 |
293 (11) |
|
| Dexamethasone |
0 |
783 (30) |
|
| Methyl prednisone or prednisone |
0 |
1,556 (59) |
|
| Start day of corticosteroids |
0 |
0 (0–4) |
|
| Corticosteroid exposure time (days) |
0 |
3 (1–13) |
|
| Total hydrocortisone equivalent (mg) |
0 |
900 (100–6,600) |
|
| Concurrent medication |
|||
| Catecholamine infusions |
2,973 (39) |
1,291 (49) |
0.0001 |
| Antibacterial antibiotics |
5,217 (68) |
2,318 (88) |
0.0001 |
| Antifungal antibiotics |
419 (5) |
557 (21) |
0.0001 |
| Diuretics |
4,360 (57) |
1,702 (65) |
0.0001 |
| Insulin |
2,424 (32) |
1,266 (48) |
0.0001 |
| Proton pump inhibitors or Histamin-2 blockade |
5,142 (67) |
2,205 (84) |
0.0001 |
| Hospital diagnosis category |
|||
| Cardiovascular |
2,348 (31) |
790 (30) |
0.5 |
| Respiratory |
1,346 (18) |
774 (29) |
0.0001 |
| Neurological |
876 (11) |
440 (17) |
0.0001 |
| Fluid and electrolytes abnormalities |
1,504 (20) |
694 (26) |
0.0001 |
| Postoperative complications |
856 (11) |
406 (15) |
0.0001 |
| Gastrointestinal |
1,023 (13) |
381 (14) |
0.2 |
| Acute renal failure |
375 (5) |
265 (10) |
0.0001 |
| Hospital outcome |
|||
| Hospital death |
327 (4) |
261 (10) |
0.0001 |
| Discharge to a care facility |
1,562 (20) |
762 (29) |
0.0001 |
|
Data presented as median (10–90% percentiles) or actual numbers (percentage). | |||
Rady et al. Critical Care 2006 10:R101 doi:10.1186/cc4971 |
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