|
Microbiological characteristics of the study cohort |
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| Control group (n = 7,626) |
Corticosteroid exposure group (n = 2,632) |
P |
|
|
|
|||
| Microbiology |
|||
| Number of patients with cultures |
3,185 (42) |
1,764 (67) |
0.0001 |
| Infection confirmed |
1,785 (23) |
1,215 (46) |
0.0001 |
| Location of infection |
n = 1,785 |
n = 1,215 |
|
| Pulmonary |
578 (32) |
489 (40) |
0.0001 |
| Abdomen |
197 (11) |
147 (12) |
0.4 |
| Genital–urinary tract |
703 (39) |
425 (35) |
0.02 |
| Bloodstream |
500 (28) |
376 (31) |
0.09 |
| Soft tissue |
165 (9) |
90 (7) |
0.08 |
| Vascular catheters |
156 (9) |
158 (13) |
0.0002 |
| Skeletal |
54 (3) |
24 (2) |
0.08 |
| Central nervous system |
46 (3) |
47 (4) |
0.05 |
| Head and neck |
17 (1) |
21 (2) |
0.07 |
| Other |
16 (1) |
9 (1) |
0.7 |
| Temporal characteristics |
n = 1,785 |
n = 1,215 |
|
| Infection episode ≤ 2 days after admission |
1,228 (69) |
820 (67) |
0.5 |
| Infection episode >2 days after admission |
883 (49) |
669 (55) |
0.003 |
| Recurrent infectiona |
633 (35) |
521 (43) |
0.0001 |
| Day of last infection episode during a hospital stay |
2 (0–13) |
3 (0–19) |
0.003 |
| Interval between first and last infection episodes (days) |
0 (0–10) |
0 (0–15) |
0.0001 |
| Interval between first and last infection episodes >2 days |
434 (24) |
402 (33) |
0.0001 |
| Types of microorganisms (culture or microscopy) |
n = 1,785 |
n = 1,215 |
|
| Bacterial |
|||
| Gram-positive cocci |
1,255 (70) |
903 (74) |
0.02 |
| Gram-negative bacilli |
744 (42) |
487 (40) |
0.4 |
| Other types of bacillib |
299 (17) |
221 (18) |
0.3 |
| Anaerobesc |
182 (10) |
112 (9) |
0.4 |
| Gram-negative cocci |
66 (4) |
38 (3) |
0.4 |
| Fungal |
404(23) |
508 (42) |
0.0001 |
| Number of types of microorganisms per location |
1 (1–4) |
2 (1–6) |
0.0001 |
| Polymicrobial infectiond |
838 (47) |
683 (56) |
0.0001 |
|
Data presented as median (10–90% percentiles) or actual numbers (percentage). Cultures included blood, sputum, urine, normally sterile body fluid or tissue. aTwo or more infection episodes during a hospital stay. blisteria, Corynebacteria, Actinomyces, bacilli Sp., Legionella and Mycobacterial species; cClostridia, Bacteroids, Peptostreptococci, and Peptococci species.. dTwo or more types of organisms present at the same location site of infection. | |||
Rady et al. Critical Care 2006 10:R101 doi:10.1186/cc4971 |
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