Critical Care

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Pharmacokinetics of recombinant activated factor VII in trauma patients with severe bleeding

Thomas Klitgaard, Rene Tabanera y Palacios, Kenneth D Boffard, Philip TC Iau, Brian Warren, Sandro Rizoli, Rolf Rossaint, Yoram Kluger, Bruno Riou* and the NovoSeven® Trauma Study Group

Critical Care 2006, 10:R104 doi:10.1186/cc4977

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Management of bleeding following major trauma: an updated European guideline

Rolf Rossaint, Bertil Bouillon, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Beverley J Hunt, Radko Komadina, Giuseppe Nardi, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Philip F Stahel, Jean-Louis Vincent, Donat R Spahn Critical Care 2010, 14:R52 (6 April 2010)

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Management of bleeding following major trauma: a European guideline

Donat R Spahn, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Giovanni Gordini, Philip F Stahel, Beverley J Hunt, Radko Komadina, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Jean-Louis Vincent, Rolf Rossaint Critical Care 2007, 11:R17 (13 February 2007)

State-of-the-art guidelines developed by a multidisciplinary task force provide evidence-based recommendations on the acute management of bleeding trauma patients, which when implemented may lead to improved patient outcomes.

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Recommendations on the use of recombinant activated factor VII as an adjunctive treatment for massive bleeding – a European perspective

Jean-Louis Vincent, Rolf Rossaint, Bruno Riou, Yves Ozier, David Zideman, Donat R Spahn Critical Care 2006, 10:R120 (18 August 2006)

European consensus guidelines, based on a systematic review of the current evidence by an expert panel, have been published on the use of recombinant activated factor VII in massive hemorrhage.