Table 3

Estimates of population average clearance and terminal half-life at various post-dose red blood cell requirements

Population

RBC requirements (Units)

Estimated clearance (ml.kg^-1.h^-1)

Terminal half-life (h)

Hemophilia^a

NA

29

4.4

Trauma

0

36

2.6

8.7^b

40

2.4

20

47

2.1

30

54

1.9

40

62

1.7

^aObtained in patients with hemophilia (see Materials and methods). ^bThis value corresponds to the trauma population average. NA, not applicable; RBC, red blood cell.

Klitgaard et al. Critical Care 2006 10:R104   doi:10.1186/cc4977