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Bivariate analysis of risk factors for in-hospital mortality in patients with septic shock |
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| Factor |
Nonsurvivors (n = 49) |
Survivors (n = 65) |
RR (95% CI) |
P |
|
|
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| Sex |
0.07 |
|||
| Male |
18 (36.7) |
35 (43.9) |
||
| Female |
31 (63.3) |
30 (46.1) |
||
| Age (years)a |
62.5 (55–75) |
60 (45–72) |
0.11 |
|
| Hepatic cirrhosis |
5 (10.2) |
4 (6.2) |
1.73 (0.35–9.21) |
0.32 |
| Immunosuppression |
4 (8.2) |
2 (3.1) |
2.8 (0.38–31.92) |
0.21 |
| COPD |
5 (10.2) |
5 (7.7) |
1.36 (0.29–6.30) |
0.42 |
| End-stage renal disease |
5 (10.2) |
3 (4.6) |
2.35 (0.43–15.79) |
0.21 |
| Chronic cardiac failure |
2 (4.1) |
2 (3.1) |
1.34 (0.09–19.07) |
0.58 |
| Diabetes mellitus |
13 (26.5) |
18 (27.7) |
0.94 (0.38–2.35) |
0.89 |
| Noncured malignancy |
6 (12.2) |
1 (1.5) |
8.9 (1.01–417) |
0.24 |
| Alcoholism |
5 (10.2) |
6 (9.2) |
1.12 (0.25–4.71) |
0.55 |
| Smoking habit |
8 (16.4) |
10 15.4) |
1.07 (0.35–3.29) |
0.89 |
| APACHE IIa |
18 (14–22) |
17 (13–21) |
0.09 |
|
| SOFA (1)a,b |
6.5 (3–11) |
8 (3–11) |
0.8 |
|
| Bacteraemia |
13 (26.5) |
26 (40) |
0.54 (0.22–1.30) |
0.2 |
| Genotype |
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| -308 TNF-α promoter polymorphism |
1.80 (0.61–5.43) |
0.42 |
||
| GG |
42 (85.7) |
50 (77) |
||
| GA/AA |
7 (14.3) |
15 (23) |
||
| TNF-β (NcoI polymorphism) |
0.66 (0.26–1.39) |
0.19 |
||
| GG/GA |
16 (32.6) |
29 (44.6) |
||
| AA |
33 (67.4) |
36 (55.4) |
||
| IL-10-1082 |
0.62 (0.18–1.96) |
0.89 |
||
| GG |
6 (12.2) |
12 |
||
| GA/AA |
43 (81.8) |
53 |
||
| Genotype TNF -308 GA/AA, TNF-β AA, IL-10-1082 GG |
1.09 (0.46–2.61) |
0.65 |
||
| Yes |
16 (32.6) |
20 |
||
| No |
33 (67.4) |
45 |
||
| Delayed AATa |
7.5 (4–28.5) |
5.5 (3–12) |
0.03 |
|
|
Unless otherwise stated, values are expressed as n (%). aResults expressed as median (25th to 75th percentiles). bSOFA (1) means SOFA score of the first 24 hours in the hospital. AAT, appropriate antibiotic therapy; APACHE, Acute Physiology and Chronic Health Evaluation; CI, confidence interval; COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; RR, relative risk; SOFA, Sequential Organ Failure Assessment. | ||||
Garnacho-Montero et al. Critical Care 2006 10:R111 doi:10.1186/cc4995 |
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