Table 5

Bivariate analysis of risk factors for in-hospital mortality in patients with septic shock

Factor

Nonsurvivors (n = 49)

Survivors (n = 65)

RR (95% CI)

P


Sex

0.07

Male

18 (36.7)

35 (43.9)

Female

31 (63.3)

30 (46.1)

Age (years)a

62.5 (55–75)

60 (45–72)

0.11

Hepatic cirrhosis

5 (10.2)

4 (6.2)

1.73 (0.35–9.21)

0.32

Immunosuppression

4 (8.2)

2 (3.1)

2.8 (0.38–31.92)

0.21

COPD

5 (10.2)

5 (7.7)

1.36 (0.29–6.30)

0.42

End-stage renal disease

5 (10.2)

3 (4.6)

2.35 (0.43–15.79)

0.21

Chronic cardiac failure

2 (4.1)

2 (3.1)

1.34 (0.09–19.07)

0.58

Diabetes mellitus

13 (26.5)

18 (27.7)

0.94 (0.38–2.35)

0.89

Noncured malignancy

6 (12.2)

1 (1.5)

8.9 (1.01–417)

0.24

Alcoholism

5 (10.2)

6 (9.2)

1.12 (0.25–4.71)

0.55

Smoking habit

8 (16.4)

10 15.4)

1.07 (0.35–3.29)

0.89

APACHE IIa

18 (14–22)

17 (13–21)

0.09

SOFA (1)a,b

6.5 (3–11)

8 (3–11)

0.8

Bacteraemia

13 (26.5)

26 (40)

0.54 (0.22–1.30)

0.2

Genotype

-308 TNF-α promoter polymorphism

1.80 (0.61–5.43)

0.42

GG

42 (85.7)

50 (77)

GA/AA

7 (14.3)

15 (23)

TNF-β (NcoI polymorphism)

0.66 (0.26–1.39)

0.19

GG/GA

16 (32.6)

29 (44.6)

AA

33 (67.4)

36 (55.4)

IL-10-1082

0.62 (0.18–1.96)

0.89

GG

6 (12.2)

12

GA/AA

43 (81.8)

53

Genotype TNF -308 GA/AA, TNF-β AA, IL-10-1082 GG

1.09 (0.46–2.61)

0.65

Yes

16 (32.6)

20

No

33 (67.4)

45

Delayed AATa

7.5 (4–28.5)

5.5 (3–12)

0.03


Unless otherwise stated, values are expressed as n (%). aResults expressed as median (25th to 75th percentiles). bSOFA (1) means SOFA score of the first 24 hours in the hospital. AAT, appropriate antibiotic therapy; APACHE, Acute Physiology and Chronic Health Evaluation; CI, confidence interval; COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; RR, relative risk; SOFA, Sequential Organ Failure Assessment.

Garnacho-Montero et al. Critical Care 2006 10:R111   doi:10.1186/cc4995

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