|
Bivariate analysis of risk factors for impairment of the inflammatory response |
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| Factor |
Impairment of the inflammatory response |
P |
||
|
|
||||
| Yes (n = 57) |
No (n = 106) |
RR (95%CI) |
||
|
|
||||
| Sex |
0.39 (0.19–0.79) |
0.004 |
||
| Male |
25 (46.3) |
71 (67) |
||
| Female |
32 (53.7) |
35 (33) |
||
| Agea |
60 (50–72) |
61 (48–70.2) |
0.5 |
|
| Hepatic cirrhosis |
8 (14) |
3 (2.8) |
5.61 (1.26–33.83) |
0.01 |
| Immunosuppression |
3 (5.3) |
3 (2.8) |
1.91 (0.25–14.67) |
0.42 |
| COPD |
3 (5.3) |
12 (11.3) |
0.44 (0.1–1.72) |
0.2 |
| End-stage renal disease |
3 (5.3) |
4 (3.8) |
1.42 (0.2–8.7) |
0.7 |
| Chronic cardiac failure |
2 (3.5) |
1 (0.94) |
3.82 (0.2–227) |
0.28 |
| Diabetes mellitus |
12 (21) |
26 (24.5) |
0.82 (0.35–1.9) |
0.61 |
| Noncured malignancy |
4 (7) |
4 (3.8) |
1.92 (0.34–10.7) |
0.71 |
| Alcoholism |
7 (12.3) |
12 (11.3) |
1.21 (0.4–3.58) |
0.85 |
| Smoking habit |
10 (17.5) |
30 (28.3) |
0.22 (0.54–1.28) |
0.12 |
| APACHE IIa |
14 (10–16.5) |
10 (6–14) |
<0.0001 |
|
| SOFA (1)a,b |
3 (2–6) |
2 (1–4) |
0.003 |
|
| Bacteraemia |
18 (31.6) |
14 (13.2) |
3.03 (1.28–7.22) |
0.005 |
| Genotype |
||||
| -308 TNF-α promoter polymorphism |
0.88 (0.33–2.37) |
0.77 |
||
| GG |
48 (84.2) |
91 (85.8) |
||
| GA/AA |
9 (15.8) |
15 (14.2) |
||
| TNF-β (NcoI polymorphism) |
1.25 (0.61–2.54) |
0.5 |
||
| GG/GA |
24 (42.1) |
39 (28.3) |
||
| AA |
33 (57.9) |
67 (63.2) |
||
| IL-10-1082 |
1.09 (0.46–2.61) |
0.8 |
||
| GG |
8 (14) |
15 (14.2) |
||
| GA/AA |
49 (86) |
91 (85.8) |
||
| Genotype -308 TNF GA/AA, TNF-β AA, IL-10-1082 GG |
1.48 (0.71–3.09) |
0.26 |
||
| Yes |
18 (31.5) |
43 (40.6) |
||
| No |
39 (68.5) |
63 (59.4) |
||
| Delayed AATa |
10 (6–25) |
5 (2.5–8) |
<0.001 |
|
|
Unless otherwise stated, values are expressed as n (%). aResults expressed as median (25th to 75th percentiles). bSOFA (1) means SOFA score of the first 24 hours in the hospital. AAT, appropriate antibiotic therapy; APACHE, Acute Physiology and Chronic Health Evaluation; CI, confidence interval; COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; RR, relative risk; SOFA, Sequential Organ Failure Assessment. | ||||
Garnacho-Montero et al. Critical Care 2006 10:R111 doi:10.1186/cc4995 |
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