Critical Care

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Recommendations on the use of recombinant activated factor VII as an adjunctive treatment for massive bleeding – a European perspective

Jean-Louis Vincent*, Rolf Rossaint, Bruno Riou, Yves Ozier, David Zideman and Donat R Spahn

Critical Care 2006, 10:R120 doi:10.1186/cc5026

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Letter   Free

Recombinant factor VIIa and factor VIII treatment for acquired factor VIII deficiency: a case of repeated thrombotic endotracheal occlusion in a mechanically ventilated patient

Stefan Lauer, Martin Westphal, Lars G Fischer, Andreas Meißner, Hugo Van Aken, Hendrik Freise Critical Care 2011, 15:407 (9 March 2011)

Research   Open Access Highly Accessed

Management of bleeding following major trauma: an updated European guideline

Rolf Rossaint, Bertil Bouillon, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Beverley J Hunt, Radko Komadina, Giuseppe Nardi, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Philip F Stahel, Jean-Louis Vincent, Donat R Spahn Critical Care 2010, 14:R52 (6 April 2010)

Poster presentation   Free

Regional variation of the off-licence use of rFVIIa for patients with uncontrolled haemorrhage in England

MH Spivey, RL Eve, MR Duffy Critical Care 2010, 14(Suppl 1):P371 (1 March 2010)

Poster presentation   Free

Analysis of the off-licence use of recombinant activated factor VII for patients with uncontrolled haemorrhage in a UK tertiary referral hospital

M Spivey, H Eve, M Duffy Critical Care 2009, 13(Suppl 1):P432 (13 March 2009)

Review   Free

Bench-to-bedside review: Latest results in hemorrhagic shock

Martin K Angele, Christian P Schneider, Irshad H Chaudry Critical Care 2008, 12:218 (10 July 2008)

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Recombinant activated factor VIIa for the treatment of bleeding in major abdominal surgery including vascular and urological surgery: a review and meta-analysis of published data

Christian von Heymann, Sven Jonas, Claudia Spies, Klaus-Dieter Wernecke, Sabine Ziemer, Detlev Janssen, Jürgen Koscielny Critical Care 2008, 12:R14 (15 February 2008)

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Safety of rFVIIa in hemodynamically unstable polytrauma patients with traumatic brain injury: post hoc analysis of 30 patients from a prospective, randomized, placebo-controlled, double-blind clinical trial

Yoram Kluger, Bruno Riou, Rolf Rossaint, Sandro B Rizoli, Kenneth Boffard, Philip Choong, Brian Warren, Michael Tillinger Critical Care 2007, 11:R85 (8 August 2007)

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Management of bleeding following major trauma: a European guideline

Donat R Spahn, Vladimir Cerny, Timothy J Coats, Jacques Duranteau, Enrique Fernández-Mondéjar, Giovanni Gordini, Philip F Stahel, Beverley J Hunt, Radko Komadina, Edmund Neugebauer, Yves Ozier, Louis Riddez, Arthur Schultz, Jean-Louis Vincent, Rolf Rossaint Critical Care 2007, 11:R17 (13 February 2007)

State-of-the-art guidelines developed by a multidisciplinary task force provide evidence-based recommendations on the acute management of bleeding trauma patients, which when implemented may lead to improved patient outcomes.