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Overview of a simplified and traditional hierarchy for grading the quality of evidence and strength of recommendations |
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| Levels of Evidence |
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| Level I |
Well conducted, suitably powered RCT |
| Level II |
Well conducted, but small and under-powered RCT |
| Level III |
Non-randomized observational studies |
| Level IV |
Non-randomized study with historical controls |
| Level V |
Case series without controls |
| Grades of recommendations |
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| Grade A |
Level I |
| Grade B |
Level II |
| Grade C |
Level III or lower |
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Levels of evidence are for an individual research investigation. Grading of recommendations is based on levels of evidence. Adapted from [1,2]. RCT, randomized controlled trial. | |
Bellomo and Bagshaw Critical Care 2006 10:232 doi:10.1186/cc5045 |
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