Table 3

Overview of the GRADE system for grading the quality of evidence: definitions in grading the quality of evidence

Level of evidence
Definition

High
Further research is not likely to change our confidence in the effect estimate
Moderate
Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate
Low
Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate
Very Low
Any estimate of effect is uncertain

Bellomo and Bagshaw Critical Care 2006 10:232   doi:10.1186/cc5045