|
Hemodynamic data and blood gas data on every continuous distending pressure in high-frequency oscillatory ventilation study protocol |
||||||
| Descent continuous distending pressure trial |
||||||
|
|
||||||
| 45 mbar |
40 mbar |
35 mbar |
30 mbar |
25 mbar |
20 mbar |
|
|
|
||||||
| Heart rate (beats/minute) |
141.5 (126–167) |
135.5 (112–153) |
128 (113–149) |
126 (107–147) |
115 (102–140) |
116 (104.5–128.5) |
| Right atrial pressure (mmHg) |
16 (15–18) |
15 (14–15) |
14.5 (13–15) |
13.5 (12–15) |
12.5 (11–13) |
11.5 (10–13)†,**,* |
| Mean pulmonary artery pressure (mmHg) |
41 (35.7–52) |
39 (35–41) |
39 (31–44) |
41 (35–42) |
39 (35–43) |
38.5 (36–42) |
| Pulmonary occlusion pressure (mmHg) |
24 (23–26) |
21.5 (20–24) |
20 (18–21) |
17 (16.2–18.7) |
14 (13.5–17)† |
13.5 (12–15)†,** |
| Left ventricular end-diastolic pressure (mmHg) |
11.5 (11–13) |
9 (9–11) |
9.5 (6–10) |
7.5 (6–12) |
7.5 (5–10)† |
5 (4–6)† |
| Mean arterial pressure (mmHg) |
85 (66–89) |
70 (63–90) |
74 (67–104) |
74.5 (66–101) |
78.5 (77–108) |
84 (47–106) |
| Cardiac output (l/minute) |
2.6 (2.3–3.1) |
2.6 (2–3) |
2.65 (2.28–3.36) |
2.52 (2.2–3.6) |
2.7 (2.2–4.2) |
3.1 (1.8–4.8) |
| Stroke volume (ml) |
19 (18–24) |
21 (16.6–24.5) |
23.6 (15–29) |
23 (15–26.9) |
18.2 (16–33) |
18.7 (12.8–37) |
| Intrathoracic blood volume (ml) |
442.5 (401–469) |
395 (335–495) |
485 (431–531) |
506.5 (453–542) |
552 (412–618) |
540 (492–614) |
| Extravascular lung water (ml) |
355 (315–476) |
360 (331–441) |
405 (287–430) |
426 (336–495) |
441 (406.5–535) |
460 (390–549) |
| Systemic vascular resistance (dyn*s/cm5) |
2,403 (1,524–2,585) |
1,598 (1,582–2,271) |
1,835 (1,567–1,997) |
2,026 (1,442–2,033) |
1,933 (1,303–2,469) |
1,611 (1,238–2,056) |
| Pulmonary vascular resistance (dyn*s/cm5) |
639 (404–859) |
440 (396–663) |
457 (376–663) |
512 (461–746) |
617 (418–970) |
678 (415–1,065) |
| Mean pulmonary artery pressure–right atrial pressure (mmHg) |
28 (19–34) |
25.5 (23–26) |
25 (18–29) |
27.5 (26–28) |
27 (25–30) |
28.5 (23–31) |
| Transpulmonary pressure (mbar) |
36 (32–43) |
31 (27–38) |
26.5 (22–33) |
21.5 (17–28) |
14.5 (12–22)†,** |
10 (7–18)†,** |
| PaO2 (Torr) |
621 (619–660) |
654 (645–683) |
664 (636–694) |
644 629–692) |
615 (469–680) |
429 (52–558)** |
| PaO2/FiO2 ratio |
82.8 (82.5–88) |
654 (645–683) |
664 (636–694) |
644 629–692) |
615 (469–680) |
429 (52–558)** |
| Oxygenation index |
7.2 (6.8–7.2) |
6.1 (5.8–6.1) |
5.4 (5–5.5) |
4.6 (4.3–4.7) |
4 (3.6–5.3) |
4.8 (3.5–37.9) |
| Oxygen delivery (ml O2/minute) |
312.5 (299–466) |
358.2 (305.6–420) |
360 (349–418) |
357.2 (338–447) |
347.4 (292–516) |
399.6 (251–548) |
| Shunt proportion |
1.03 (0.4–3) |
0.7 (0.1–1.4) |
1.5 (0–4.3) |
1.6 (1.1–4.9) |
4.7 (4.2–11.3) |
20.2 (7.2–52)†,** |
| PaCO2 (Torr) |
38.5 (28.3–46.6) |
40.3 (30.1–51.1) |
37.4 (30.7–44.8) |
41.2 (31.1548) |
46.9 (32.9–61.2) |
54.5 (40.7–68.6)†,* |
| Oxygen saturation (%) |
99.9 (99–100) |
99.9 (99.8–100) |
99.9 (99.9–100) |
99.9 (98.3–100) |
99.9 (96–100) |
99.8 (83–99) |
| pH |
7.41 (7.37–7.5) |
7.4 (7.34–7.53) |
7.4 (7.38–7.51) |
7.4 (7.38–7.51) |
7.38 (7.35–7.48) |
7.29 (7.25–7.4) |
| Standard bicarbonate (mmol/l) |
25 (24.2–29.8) |
25.8 (25–27) |
26 (23.4–27.6) |
25.1 (23.5–27.7) |
25.3 (24.2–28.5) |
24.6 (24.1–28.5) |
| Base excess |
0.95 (0.4–6.2) |
1 (-1.5 to 5.2) |
02 (-0.65 to 2.97) |
-0.15 (-2.4 to 1.6) |
-1.35 (-2.3 to 1.4) |
0.2 (-4.25 to 0.47) |
| Hemoglobin (g/dl) |
7.9 (7.1–9.7) |
8.8 (7.4–10.1) |
8.2 (7.5–10.4) |
8 (7.4–9.7) |
7.9 (7.1–9.4) |
7.8 (7–10) |
|
Data presented as median (25th–75th percentiles). Significant differences in parameters are indicated: *P < 0.05 vs 35 mbar, **P < 0.05 vs 40 mbar, †P < 0.05 vs 45 mbar. | ||||||
Karmrodt et al. Critical Care 2006 10:R138 doi:10.1186/cc5052 |
||||||