Table 3 |
|
|
Effect of non-specific therapy on coagulation and fibrinolysis |
|
|
Plasma infusion |
Plasma exchange |
|
|
|
|
Restores procoagulant factors |
Restores procoagulant factor homeostasis |
|
Restores anticoagulant factors (protein C, antithrombin III, TFPI) |
Restores anticoagulant factor homeostasis (protein C, antithrombin III, TFPI) |
|
Restores prostacyclin |
Restores prostacyclin homeostasis |
|
Restores tPA |
Restores tPA homeostasis |
|
Restores ADAMTS 13 |
Restores ADAMTS 13 homeostasis |
|
Removes ADAMTS 13 inhibitors |
|
|
Removes ultra-large vWF multimers |
|
|
Removes tissue factor |
|
|
Removes excess PAI-1 |
|
|
|
|
|
PAI, plasminogen activator inhibitor type I; TFPI, tissue factor pathway inhibitor; tPA, tissue plasminogen activator; vWF, von Willebrand factor. |
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|
Nguyen and Carcillo Critical Care 2006 10:235 doi:10.1186/cc5064 |
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