Table 1

Cytokine levels

Control

LPS

APC

LPS + APC

TNF-α

355 ± 243

1,766 ± 168^a

402 ± 297

1,773 ± 138^a

IL-1β

106 ± 108

3,298 ± 1,355^a

65 ± 21

4,820 ± 1,554^a

IL-6

579 ± 283

8,366 ± 642^a

604 ± 263

8,336 ± 439^a

IL-10

246 ± 142

1,698 ± 359^a

267 ± 150

2,076 ± 219^a

Cytokine levels (pg/ml) two hours after endotoxin challenge (mean ± standard deviation). ^ap < 0.05 versus controls. APC, activated protein C-only group; IL, interleukin; LPS, lipopolysaccharide-only group; LPS + APC, activated protein C-treated endotoxaemic group; TNF-α, tumour necrosis factor-α.

Lehmann et al. Critical Care 2006 10:R157   doi:10.1186/cc5093