Table 5

Hyperlactatemia during CPB and postoperative outcome

Univariate analysis (Student's t test)

Corrected^a values

Outcome variable

No HL (n = 443)

HL (n = 27)

p

P

Peak serum creatinine (mg/dl)

1.3 ± 1.1

2.1 ± 1.4

0.001

0.45

MV time (hours)

22.6 ± 55

57.4 ± 68

0.015

0.41

ICU stay (days)

2.5 ± 3.4

5.3 ± 5.4

0.012

0.04

Univariate analysis (RR)

Corrected^b values

Outcome variable

No HL (n = 443)

HL (n = 27)

RR (95% CI)

OR (95% CI)

Prolonged (> 7 days) ICU stay

18 (4.1%)

5 (18.5%)

5.3 (1.8–15.8)

4.2 (1.04–17)

Prolonged (> 48 hours) MV

21 (4.7%)

9 (33.3%)

10 (4–25)

4.9 (1.6–15)

Surgical revision

19 (4.3%)

5 (18.5%)

5.1 (1.7–14.8)

2.5 (0.6–9.5)

Intra-aortic balloon pump

2 (0.4%)

3 (11.1%)

27.5 (4.4–172)

23 (2.7–207)

Atrial fibrillation

75 (17%)

9 (33.3%)

2.4 (1.06–5.6)

1.6 (0.6–4.1)

Severe lung dysfunction

6 (1.3%)

2 (7.4%)

5.8 (1.1–30.3)

0.8 (0.1–8.5)

Sepsis

9 (2%)

3 (11.1%)

6 (1.5–23.7)

3.6 (0.6–21)

Composite morbidity index

36 (8.1%)

9 (33.3%)

5.6 (2.4–13.5)

2.9 (1.03–8.5)

Hospital mortality

5 (1.1%)

3 (11.1%)

10.9 (2.5–48)

2.5 (0.37–18)

^aValues obtained including preoperative serum creatinine value, active endocarditis, and CPB duration into a multivariate linear regression; ^bvalues obtained including preoperative serum creatinine value, active endocarditis, and CPB duration into a multivariate logistic regression. CI, confidence interval; CPB, cardiopulmonary bypass; HL, hyperlactatemia; ICU, intensive care unit; MV, mechanical ventilation; OR, odds ratio; RR, relative risk.

Ranucci et al. Critical Care 2006 10:R167   doi:10.1186/cc5113