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Vasoactive drugs utilized in treating sepsis-induced hypoperfusion |
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| Drug |
Dosage |
Comments |
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| Dobutamine |
1–40 μg/kg per min |
Strong inotropic effect may produce vasodilation; utilized as pure inotrope agent. |
| Causes tachycardia |
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| Dopamine |
1–20 μg/kg per min |
Effects vary with dose. Predominantly vasoconstrictor with positive inotropy. |
| Causes tachycardia. Effects on renal vasculature are not protective against renal failure |
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| Epinephrine |
1–20 μg/min |
Strong inotropic, chronotropic, and vasoconstrictor. |
| Concerns about ischemia and splanchnic circulation |
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| Norepinephrine |
0.03–1.5 μg/kg per min |
Strong vasoconstrictor with modest effect on contractility. Does not produce tachycardia |
| Phenylephrine |
0.5–8 μg/kg per min |
Pure vasoconstrictor. No effect on contractility or heart rate |
| Vasopressin |
0.01–0.04 U/min |
Not recommended as first-line agent. Increases blood pressure; may cause splanchnic and cardiac ischemia |
Zanotti Cavazzoni and Dellinger Critical Care 2006 10(Suppl 3):S2 doi:10.1186/cc4829 |
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