Searching for non-invasive markers of tissue hypoxia

doi:10.1186/cc5691

Critical Care
Volume 11
Issue 1

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Commentary

Searching for non-invasive markers of tissue hypoxia

Juan Carlos Puyana¹ and Michael R Pinsky²

¹Associate Professor of Surgery and Critical Care, Director Applied Research IMITs Center, Innovative Medical & Information Technology Center, UPMC, F1265 Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213-2536, USA

²Professor of Critical Care Medicine, Bioengineering and Anesthesiology, 606 Scaife Hall 3550 Terrace Street, Pittsburgh, PA 15261, USA

author email corresponding author email

Critical Care 2007, 11:116doi:10.1186/cc5691


Published:	23 February 2007

See related research by Podbregar and Možina, http://ccforum.com/content/11/1/R6

Abstract

Tissue hypoxia is a common end product of circulatory shock and a primary target for resuscitation efforts. In this issue Podbregar and Mozina show that thenar tissue O₂saturation (StO₂) and mixed venous O₂saturation (SvO₂) co-vary in patients in left ventricular failure, but in patients with sepsis StO₂was higher than SvO₂. Although StO₂may co-vary with SvO₂they have different determinants such that after shock StO₂may increase well before SvO₂as a result of increased O₂demands to repay O₂debt incurred during hypoperfusion. Thus, the use of StO₂alone to define the endpoint of resuscitation may be misleading.