Table 3

Liver serum markers
	Group	T_baseline	T_ALI	T_{6 h}	T_{18 h}	T_{24 h}

AST, U/l	PCV	26 (24–30)	29 (27–32)^a	50 (42–58)^a,b	81 (69–155)^a-c	150 (103–191)^a-d
	PCV+R	31 (25–38)	29 (28–37)	126 (64–231)^a,b	138 (105–197)^a,b	262 (230–364)^a-e
ALT, U/l	PCV	31.2 (24.8–35.5)	28.1 (25.4–29.9)^a	26 (25.1–28.7)^a	25.6 (20.2–31.6)^a	23.5 (20.1–30)^a
	PCV+R	39.3 (36–44.7)	36.3 (31.5–41)	37.6 (34.6–40.7)^e	32.5 (30.5–36.8)	37.3 (33.8–37.8)
GGT, U/l	PCV	42.5 (37.6–43.2)	35.7 (32.9–38.6)^a	37.6 (31.9–40.6)^a	36.5 (31–38.4)^a	34.3 (29.1–34.7)^a
	PCV+R	37.8 (34.3–42.7)	38.5 (30–41.6)	34.6 (28.4–38.2)^a,b	33.6 (27.8–36.6)^a,b	33.3 (27–35.6)^a,b
LDH, U/l	PCV	544 (482–585)	498 (442–545)	550 (492–606)^a,b	587 (565–814)^a,b	647 (580–921)^a,b
	PCV+R	607 (437–716)	565 (474–799)	677 (645–1,039)^a,b	1,012 (653–1,689)^a-c	1,262 (872–2,082)^a-e
AP, U/l	PCV	99 (71–122)	91 (64–123)^a	92 (70–113)^a	93 (65–106)^a	84 (60–110)^a-d
	PCV+R	82 (79–94)	78 (76–89)	88 (82–98)	87 (82–93)	86 (78–90)
ChE, U/l	PCV	356 (339–471)	357 (307–422)	387 (315–433)	363 (323–403)	318 (297–417)
	PCV+R	431 (359–461)	381 (353–437)^a	413 (333–425)^a	358 (339–429)^a	368 (339–423)^a
TotBili, μmol/l	PCV	3.4 (3.0–5.1)	1.7 (1.7–2.1)	2.6 (1.7–3.4)	3.4 (1.7–5.1)	3.4 (1.7–3.8)
	PCV+R	4.3 (3.4–7.3)	3.4 (3.0–4.3)^a	6.8 (6.0–9.0)^a,b,e	6.8 (4.7–7.3)^a,b	8.6 (6.4–9.4)^a,b,e
DirBili, μmol/l	PCV	0.8 (0.5–0.9)	0.3 (0.2–0.5)	0.4 (0.3–0.7)	0.6 (0.3–1.0)	0.6 (0.3–1.0)
	PCV+R	0.7 (0.5–0.9)	0.7 (0.5–1.1)^e	1.4 (0.6–1.8)^e	1.6 (1.3–1.8)^e	2.2 (1.7–2.3)^e
Lactate, mmol/l	PCV	4.2 (2.9–10.4)	1 (1–1.6)^a	0.7 (0.7–0.9)^a,b	0.7 (0.7–0.8)^a,b	0.7 (0.5–0.9)^a,b
	PCV+R	4 (3.2–6.8)	0.9 (0.8–1.1)^a	1.3 (1.2–2.1)^a,b,e	0.9 (0.8–1)^a,c	1 (0.9–1.2)^a,c,e

Data are presented as the median (interquartile range). ^a-dFriedman repeated measures analysis of variance on rank with all pairwise multiple comparison procedures (Student-Newman-Keuls method). ^aversus T_baseline, ^bversus T_ALI, ^cversus T_{6 h}, ^dversus T_{18 h}(p < 0.05). ^eMann-Whitney rank sum test: p < 0.05 versus PCV. ALT, alanine aminotransferase; AP, alkaline phosphatase; AST, aspartate aminotransferase; ChE, cholinesterase; DirBili, direct bilirubin GGT, γ-glutamyltransferase; LDH, lactate dehydrogenase; PCV, pressure-controlled ventilation; PCV+R, pressure-controlled ventilation with recruitment manoeuvre; T_{6 h}, time point 6 hours after randomisation; T_{18 h}, time point 18 hours after randomisation; T_{24 h}, time point 24 hours after randomisation; T_ALI, time point after lung injury; T_baseline, baseline time point; TotBili, total bilirubin.
Kredel et al. Critical Care 2007 11:R13 doi:10.1186/cc5674