Table 3 |
||||||
|
IL-1β mRNA expression (logIL1) and PMI (logPMI) sorted by lung region |
||||||
|
LVHP-S |
HVLP-S |
HVLP-P |
OA |
NIR |
C |
|
|
|
||||||
|
n = 10 |
n = 10 |
n = 10 |
n = 10 |
n = 4 |
n = 5 |
|
|
|
||||||
|
Mean (SD) |
Mean (SD) |
Mean (SD) |
Mean (SD) |
Mean (SD) |
Mean (SD) |
|
|
|
||||||
|
logIL1 nondependent |
0.1262 (0.1117) |
0.3102 (0.0807) |
0.2479 (0.1472) |
0.2804 (0.1129) |
-- |
-1.4306 (0.1692) |
|
logIL1 dependent |
0.1166 (0.1674) |
0.2078 (0.1079) |
0.2784 (0.1748) |
0.2657 (0.1758) |
-- |
-1.4749 (0.0646) |
|
logPMI nondependent |
0.0363 (0.1349) |
0.1518 (0.1345) |
0.1725 (0.1255) |
0.1721 (0.1273) |
-0.738 (0.1359) |
-- |
|
logPMI dependent |
0.0291 (0.0848) |
0.1545 (0.1286) |
0.2347 (0.1272) |
0.1372 (0.1287) |
-0.7697 (0.1276) |
-- |
|
|
||||||
|
Results are expressed as mean and standard deviation (SD). Post hoc analysis for IL-1β expression: significant differences found between groups: (i) C versus HVLP-P, C versus HVLP-S, C versus LVHP-S, and C versus OA, p < 0.001; (ii) LVHP-S versus HVLP-P, p = 0.014; (iii) LVHP-S versus HVLP-S, p = 0.019; (iv) LVHP-S versus OA, p = 0.007. Post hoc analysis for PMI: significant differences found between groups: (i) NIR versus HVLP-P, NIR versus HVLP-S, NIR versus LVHP-S, and NIR versus OA, p < 0.001; (ii) LVHP-S versus HVLP-P, p < 0.001; (iii) LVHP-S versus HVLP-S, p = 0.026; (iv) LVHP-S versus OA, p = 0.024. C, control group; HVLP-P, high volume-low positive end-expiratory pressure, prone; HVLP-S, high volume-low positive end-expiratory pressure, supine; IL-1β, interleukin-1-beta; logIL1: logarithmic transformation of the expression of IL-1β mRNA normalized by GAPDH mRNA; logPMI, logarithm of the polymorphonuclear infiltratrion index; LVHP-S, low volume-high positive end-expiratory pressure, supine; NIR, no injury, recruited; OA, oleic acid injury, no ventilation; PMI, polymorphonuclear infiltrate. |
||||||
|
de Carvalho et al. Critical Care 2007 11:R23 doi:10.1186/cc5702 |
||||||
