Table 3 |
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|
Levels of HMGB1, PCT, LBP, CRP, IL-6, WBC, and neutrophils in different groups |
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|
Variable |
Healthy controls (n = 32) |
Non-infected patients (n = 67) |
Infected patients without SIRS (n = 32) |
Patients with sepsis (n = 47) |
Patients with severe sepsis (n = 27) |
P valuea |
|
|
||||||
|
HMGB1 (ng/ml) |
< 0.001 |
|||||
|
Median |
0.77 |
1.54 |
2.41 |
2.24 |
2.18 |
|
|
IQR |
0.6–1.46 |
0.79–2.88 |
0.63–3.44 |
1.30–3.75 |
0.91–3.85 |
|
|
PCT (ng/ml) |
< 0.001 |
|||||
|
Median |
0.09 |
0.16 |
0.2 |
1.9 |
||
|
IQR |
0.05–0.13 |
0.07–0.34 |
0.08–0.65 |
0.22–14.6 |
||
|
LBP (μg/ml) |
< 0.001 |
|||||
|
Median |
16.3 |
27.4 |
33.5 |
40.4 |
||
|
IQR |
12.05–25.3 |
18.3–41.2 |
25.0–43.2 |
18.0–63.6 |
||
|
CRP (mg/l) |
< 0.001 |
|||||
|
Median |
18 |
122.0 |
120.0 |
217.0 |
||
|
IQR |
10–42 |
54.0–215.0 |
41.0–190.0 |
78.0–414.0 |
||
|
IL-6 (pg/ml) |
< 0.001 |
|||||
|
Median |
9.8 |
20.6 |
72.6 |
199.3 |
||
|
IQR |
2.85–21.65 |
9.8–99.4 |
25.9–274.5 |
67.5–2,833.0 |
||
|
WBC count (109/l) |
< 0.001 |
|||||
|
Median |
8.2 |
9.5 |
13.0 |
12.2 |
||
|
IQR |
6.7–10.3 |
7.7–11.9 |
9.2–17.1 |
7.0–17.5 |
||
|
Neutrophils (109/l) |
< 0.001 |
|||||
|
Median |
6.19 |
7.1 |
10.1 |
10.3 |
||
|
IQR |
4.73–7.9 |
5.1–9.7 |
7.1–14.8 |
5.5–15.4 |
||
|
sCD163 (mg/l) |
0.06 |
|||||
|
Median |
2.99 |
3.62 |
3.17 |
3.63 |
||
|
IQR |
2.21–4.05 |
2.44–4.54 |
2.27–4.64 |
2.67–5.72 |
||
|
|
||||||
|
aKruskal-Wallis test. CRP, C-reactive protein; HMGB1, high mobility group box-1 protein; IL-6, interleukin-6; IQR, interquartile range; LBP, lipopolysaccharide-binding protein; PCT, procalcitonin; sCD163; soluble haemoglobin scavenger receptor; SIRS, systemic inflammatory response syndrome; WBC, white blood cell. |
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|
Gaïni et al. Critical Care 2007 11:R32 doi:10.1186/cc5715 |
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