Table 3 |
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Accuracy of the six inflammatory markers and the combined three-marker and three-marker tests in diagnosing bacterial infection in SIRS patients |
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|
Biomarker |
Sensitivity (95% CI)a |
Specificity (95% CI)a |
AUC (95% CI) |
Specificity = 0.7 |
Specificity = 0.8 |
Positive predictive valueb |
Negative predictive valueb |
|
|
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|
Sensitivity (95% CI) |
Sensitivity (95% CI) |
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|
|
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|
CRP |
0.86 (0.78–0.93) |
0.60 (0.46–0.73) |
0.81 (0.73–0.86) |
0.72 (0.62–0.81) |
0.67 (0.56–0.76) |
0.79 |
0.73 |
|
PCT |
0.80 (0.71–0.88) |
0.58 (0.44–0.71) |
0.72 (0.63–0.79) |
0.69 (0.58–0.78) |
0.51 (0.41–0.61) |
0.80 |
0.63 |
|
Neutrophil count |
0.74 (0.64–0.82) |
0.64 (0.50–0.76) |
0.74 (0.66–0.81) |
0.70 (0.60–0.79) |
0.59 (0.49–0.69) |
0.82 |
0.57 |
|
MIF |
0.80 (0.71–0.88) |
0.47 (0.34–0.61) |
0.63 (0.53–0.72) |
0.41 (0.31–0.51) |
0.29 (0.20–0.39) |
0.73 |
0.58 |
|
sTREM-1 |
0.82 (0.73–0.89) |
0.40 (0.27–0.54) |
0.61 (0.52–0.71) |
0.36 (0.27–0.47) |
0.32 (0.23–0.43) |
0.71 |
0.56 |
|
suPAR |
0.35 (0.26–0.46) |
0.67 (0.53–0.79) |
0.50 (0.40–0.60) |
0.31 (0.22–0.42) |
0.23 (0.15–0.33) |
0.65 |
0.37 |
|
3-markerc |
0.67 (0.56–0.76) |
0.89 (0.78–0.96) |
0.84 (0.71–0.91) |
0.76 (0.66–0.84) |
0.70 (0.60–0.79) |
0.91 |
0.60 |
|
6-markerd |
0.88 (0.79–0.93) |
0.78 (0.65–0.88) |
0.88 (0.81–0.92) |
0.89 (0.80–0.94) |
0.84 (0.76–0.91) |
0.88 |
0.78 |
|
|
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|
aSensitivity and specificity of C-reactive protein (CRP), procalcitonin (PCT) and neutrophil count were computed using the predefined cutoff values of 60 mg/l, 0.25 μg/l and 7.5 × 109 cells/l, respectively. Sensitivity and specificity of macrophage migration inhibitory factor (MIF), soluble triggering receptor expressed on myeloid cells (sTREM)-1, soluble urokinase-type plasminogen activator receptor (suPAR), and the three-marker and six-marker tests were computed using optimal cutoff values determined using Youdens Index. bPositive and negative predictive values were calculated using Youdens Index-determined optimal cutoffs for all markers. The optimal cutoffs were 59 mg/l for CRP, 0.28 μg/l for PCT, 8.5 × 109 cells/l for neutrophil count, 0.81 μg/l for MIF, 3.5 μg/l for sTREM-1, 2.7 μg/l for suPAR, 6.1 for the three-marker test and 4.1 for the six-marker test. cThree-marker test = 0.160 × neutrophil count + 0.981 × log(CRP) + 0.107 × log(PCT). dSix-marker test = -0.551 × log(suPAR) + 0.254 × log(sTREM-1) + 0.416 × log(MIF) + 0.098 × neutrophils + 0.639 × log(CRP) + 0.201 × log(PCT). AUC, area under the receiver operating characteristic curve; CI confidence interval. |
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|
Kofoed et al. Critical Care 2007 11:R38 doi:10.1186/cc5723 |
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