Table 1

Characteristics of included studies: parallel-design studies
Study
 Year
 Country of origin
 Randomization
 Conventional therapy
 PMX-F




N
 Percentage of males
 APACHE II score
 Predicted mortality (percentage)
 N
 Percentage of males
 APACHE II score
 Predicted mortality (percentage)
Tani et al. [21] (a)a
 1998
 Japan
 No
 33
 69.7
 SSS 39.1
 N/A
 37
 78.4
 SSS 46.2
 N/A
Nakamura et al. [10]
 1999
 Japan
 Yes
 20
 60.0
 NS
 N/A
 30
 60.0
 24.8
 52.6
Nemoto et al. [14]
 2001
 Japan
 Yes
 44
 61.4
 23
 46.0
 54
 64.7
 22
 42.4
Nakamura et al. [11] (a)
 2002
 Japan
 Yes
 9
 66.7
 27.5
 62.2
 9
 66.7
 28.5
 65.6
Suzuki et al. [15]
 2002
 Japan
 Yes
 24
 70.8
 25
 53.3
 24
 75.0
 25
 53.3
Tsushima et al. [33]
 2002
 Japan
 No
 10
 80.0
 NS
 N/A
 24
 70.8
 22.4
 43.9
Tsugawa et al. [31]
 2002
 Japan
 No
 51
 43.1
 NS
 N/A
 31
 45.2
 NS
 N/A
Nakamura et al. [8] (b)
 2003
 Japan
 Yes
 10
 60.0
 27
 60.5
 10
 60.0
 27.6
 62.5
Nakamura et al. [12] (c)
 2003
 Japan
 Yes
 25
 64.0
 23
 46.4
 35
 68.6
 24.2
 50.4
Nakamura et al. [29] (d)
 2003
 Japan
 No
 108
 62.0
 24
 49.7
 206
 64.1
 24.6
 51.9
Nakamura et al. [13] (e)
 2004
 Japan
 Yes
 10
 60.0
 28
 63.9
 15
 60.0
 28.4
 65.2
Nakamura et al. [9] (f)
 2004
 Japan
 Yes
 50
 64.0
 24.8
 52.6
 70
 61.4
 25.4
 54.8
Ono et al. [30]
 2004
 Japan
 No
 13
 61.5
 8.8
 9.7
 10
 60.0
 19.6
 34.2
Tsujimoto et al. [32]
 2004
 Japan
 No
 10
 20.0
 10.6
 12.2
 7
 85.7
 19.4
 33.5
Nakamura et al. [19] (g)
 2005
 Japan
 No
 12
 58.3
 25
 53.3
 14
 64.3
 25.5
 55.1
Vincent et al. [28]
 2005
 Belgium, UK, Germany, Netherlands, Spain
 Yes
 18
 47.4
 18.7
 31.3
 17
 76.5
 16.7
 25.4
Total


447


593


aTwo studies reported severity of illness as SSS rather than APACHE score.

APACHE II score expressed as the mean. Predicted mortality was calculated as eLogit/(1+ eLogit), where Logit = -3.517 + (APACHE II) × 0.146. APACHE, Acute Physiology and Chronic Health Evaluation; N/A, not applicable; NS, not stated; PMX-F, polymyxin B-immobilized fiber column; SSS, Sepsis Severity Score.

Cruz et al. Critical Care 2007 11:R47   doi:10.1186/cc5780