Kidney function assessment in the critically ill child: is it time to leave creatinine behind?

doi:10.1186/cc5935

Critical Care
Volume 11
Issue 3

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Commentary

Kidney function assessment in the critically ill child: is it time to leave creatinine behind?

Stuart L Goldstein

Texas Children's Hospital, 6621 Fannin Street, MC 3-2482, Houston, TX 77030, USA

author email corresponding author email

Critical Care 2007, 11:141doi:10.1186/cc5935


Published:	15 June 2007

See related research by Herrero-Morín et al., http://ccforum.com/content/11/3/R59

Abstract

The accurate diagnosis of acute kidney injury (AKI) is especially problematic in critically ill patients in whom renal function is in an unsteady state, rendering creatinine-based baseline assessment measures of renal function potentially inadequate. Herrero-Morin and colleagues performed a cross-sectional analysis of the ability of cystatin C and β₂microglobulin to reflect creatinine clearance in pediatric patients with AKI. The aim of this commentary is to review the current state of AKI clinical and translational research in the light of the results presented in that study.