Kidney function assessment in the critically ill child: is it time to leave creatinine behind?
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Correspondence: Stuart L Goldstein stuartg@bcm.edu
Texas Children's Hospital, 6621 Fannin Street, MC 3-2482, Houston, TX 77030, USA
Critical Care 2007, 11:141 doi:10.1186/cc5935
Published: 15 June 2007Abstract
The accurate diagnosis of acute kidney injury (AKI) is especially problematic in critically ill patients in whom renal function is in an unsteady state, rendering creatinine-based baseline assessment measures of renal function potentially inadequate. Herrero-Morin and colleagues performed a cross-sectional analysis of the ability of cystatin C and β2 microglobulin to reflect creatinine clearance in pediatric patients with AKI. The aim of this commentary is to review the current state of AKI clinical and translational research in the light of the results presented in that study.