Research
Injurious mechanical ventilation in the normal lung causes a progressive pathologic change in dynamic alveolar mechanics
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* Corresponding author: Scott Albert albertsc@upstate.edu
1 Department of Surgery, SUNY Upstate Medical University, 750 East Adams St Syracuse, NY 13210, USA
2 Memorial Health University Medical Center, 4700 Waters Ave Savannah, GA 31404, USA
3 Department of Biological Sciences, SUNY Cortland, P.O. Box 2000 Cortland, NY 13045, USA
Critical Care 2007, 11:R64 doi:10.1186/cc5940
Published: 12 June 2007Additional files
A movie file illustrating stable subpleural alveoli in the normal rat lung during dynamic tidal ventilation. Each sphere-shaped object is an inflated individual alveolus and there is minimal atelectasis (that is, the entire field is covered by inflated alveoli). Notice there is minimal alveolar movement (that is, alveoli are stable) during tidal ventilation, at least in the two dimensions that can be seen with our in vivo microscope technique.
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A movie file demonstrating unstable subpleural alveoli in the injured rat lung during dynamic tidal ventilation. The red area without alveoli (that is, individual circles) shows diffuse atelectasis prior to inspiration. The individual alveoli (spheres) 'pop' open with inspiration and then quickly collapse with expiration. Notice that alveoli are very unstable and there is complete collapse of most alveoli during deflation and than reinflation during lung inflation – classic alveolar recruitment/derecruitment.
Format: MPG Size: 447KB Download file
Playing the movie within this page requires QuickTime 6.4 or later and JavaScript. Read more