Table 1

Hemodynamic and pulmonary parameters

Baseline

15 minutes

30 minutes

45 minutes

60 minutes

75 minutes

90 minutes

Control group

Mean arterial pressure (mmHg)

102 ± 17

111 ± 10

123 ± 7

138 ± 0

143 ± 8

124 ± 10

105 ± 20

pH

7.32 ± 0.05

7.32 ± 0.10

7.30 ± 0.10

7.26 ± 0.01

7.26 ± 0.02

7.26 ± 0.05

7.26 ± 0.02

PCO2 (mmHg)

28 ± 9

40 ± 1

36 ± 0

37 ± 4

34 ± 5

29 ± 2

23 ± 5

PO2 (mmHg)

241 ± 81

316 ± 18

325 ± 36

298 ± 16

331 ± 37

334 ± 10

340 ± 12

Tidal volume (ml/kg)

15.0 ± 5.9

7.8 ± 1.3

7.8 ± 1.3

7.8 ± 1.3

6.9 ± 1.6

7.9 ± 1.4

9.9 ± 1.8

Peak pressure (cmH2O)

16 ± 0

15 ± 1

16 ± 0

16 ± 0

16 ± 0

16 ± 0

16 ± 0

Intravenous fluid (ml)

9.3 ± 0.7

High pressure/low PEEP group

Mean arterial pressure (mmHg)

92 ± 13

79 ± 10

89 ± 10

86 ± 9*

71 ± 11*

64 ± 11*

55 ± 10#

pH

7.25 ± 0.06

7.39 ± 0.05#

7.37 ± 0.04#

7.33 ± 0.03

7.31 ± 0.04

7.24 ± 0.04

7.20 ± 0.03

PCO2 (mmHg)

30 ± 6

23 ± 5*†

22 ± 4

21 ± 4

17 ± 3*

16 ± 3

15 ± 4

PO2 (mmHg)

187 ± 32

241 ± 37

260 ± 42

240 ± 54

244 ± 59

251 ± 54

232 ± 45

Tidal volume (ml/kg)

12.2 ± 5.9

31.4 ± 5.5*#†

30.3 ± 3.9*#†

27.7 ± 2.6*#†

38.4 ± 10.8*#†

40.0 ± 13.2#†

39.0 ± 9.2*#†

Peak pressure (cmH2O)

17 ± 0*

39 ± 4*

45 ± 1*

45 ± 1*

45 ± 1*

45 ± 1*

46 ± 2*

Intravenous fluid (ml)

12.6 ± 2.9

High pressure/high PEEP group

Mean arterial pressure (mmHg)

105 ± 23

94 ± 13

100 ± 16

85 ± 14*

84 ± 20*

83 ± 16

66 ± 14

pH

7.40 ± 0.05

7.27 ± 0.04

7.32 ± 0.08

7.28 ± 0.03

7.27 ± 0.04

7.23 ± 0.06#

7.22 ± 0.09#

PCO2 (mmHg)

32 ± 3

44 ± 3

33 ± 7

26 ± 4

25 ± 3

19 ± 1

15 ± 1#

PO2 (mmHg)

263 ± 32

262 ± 40

315 ± 14

307 ± 27

317 ± 20

315 ± 11

317 ± 17

Tidal volume (ml/kg)

12.9 ± 1.4

8.6 ± 2.4#

9.6 ± 2.5#

9.6 ± 2.6#

9.6 ± 2.6#

9.2 ± 2.4#

9.2 ± 2.4#

Peak pressure (cmH2O)

17 ± 0*

50 ± 3*

50 ± 6*

50 ± 3*

50 ± 3*

50 ± 3*

50 ± 6*

Intravenous fluid (ml)

9.0 ± 1.9

Data presented as the mean ± standard error. PCO2 (partial pressure of carbon dioxide); PO2 (partial pressure of oxygen). *P < 0.05 versus control group, #P < 0.05 versus baseline, †P < 0.05 versus the high pressure/high positive end-expiratory pressure (PEEP) group.

Pavone et al. Critical Care 2007 11:R64   doi:10.1186/cc5940

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