Factor VII and the brain: time to get this research done!

doi:10.1186/cc6097

Critical Care
Volume 11
Issue 4

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Factor VII and the brain: time to get this research done!

Richard P Dutton

University of Maryland School of Medicine, R Adams Cowley Shock Trauma Center, University of Maryland Medical System, MA, USA

author email corresponding author email

Critical Care 2007, 11:161doi:10.1186/cc6097


Published:	31 August 2007

See related research by Kluger et al., http://ccforum.com/content/11/4/R85

Abstract

Traumatic brain injury is the leading killer after trauma, in part because of coagulopathy. Factor VIIa may be a useful therapy in this setting, depending on the relative risk for thromboembolic complications. Kluger and coworkers recently conducted a retrospective review of patients with traumatic brain injury from a previous factor VIIa and trauma trial. It documents an encouragingly low rate of complications, and should provide a strong incentive to conduct a prospective study of factor VIIa in patients with severe traumatic brain injury.