Marcus J Schultz1,2,3
, Michael Kuiper2,4
, Peter E Spronk2,5
, Margreeth B Vroom1
and Ognjen Gajic6 
1
Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
2
Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
3
HERMES Critical Care Group, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
4
Department of Intensive Care Medicine, Medical Center Leeuwarden, Henri Dunantweg 2, 8934 AD, Leeuwarden, The Netherlands
5
Department of Intensive Care Medicine, Gelre Hospital, location Lukas, Albert Schweitzerlaan 31, 7334 DZ Apeldoorn, The Netherlands
6
Department of Intensive Care Medicine, Mayo Clinic, First Street 200 SW, Rochester, MN 55905, USA