Marcus J Schultz1,2,3
, Michael Kuiper2,4
, Peter E Spronk2,5
, Margreeth B Vroom1
and Ognjen Gajic6 
1Department of Intensive Care Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
2Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
3HERMES Critical Care Group, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
4Department of Intensive Care Medicine, Medical Center Leeuwarden, Henri Dunantweg 2, 8934 AD, Leeuwarden, The Netherlands
5Department of Intensive Care Medicine, Gelre Hospital, location Lukas, Albert Schweitzerlaan 31, 7334 DZ Apeldoorn, The Netherlands
6Department of Intensive Care Medicine, Mayo Clinic, First Street 200 SW, Rochester, MN 55905, USA