Table 1 |
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Physiologic conditions at the beginning and end of ventilation |
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|
Nonventilated |
Tidal volume 30 ml/kg |
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|
|
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|
Room air |
Hyperoxia |
Room air |
Hyperoxia |
|
|
|
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|
pH |
7.40 ± 0.03 |
7.35 ± 0.01 |
7.33 ± 0.04 |
7.35 ± 0.03 |
|
PaO2 (mmHg) |
98.7 ± 0.4 |
421.3 ± 5.3 |
86.1 ± 0.8 |
409.1 ± 4.1 |
|
PaCO2 (mmHg) |
40.2 ± 0.3 |
39.1 ± 0.8 |
35.3 ± 1.4 |
43.1 ± 1.8 |
|
mean arterial pressure (mmHg) |
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|
Start |
86 ± 1.3 |
85.3 ± 2.1 |
84.6 ± 1.6 |
83.0 ± 2.8 |
|
End |
85.2 ± 0.7 |
84.8 ± 0.9 |
73.5 ± 5.0 |
71.9 ± 4.3 |
|
Evans blue dye (ng/mg lung weight) |
14.1 ± 1.3 |
15.9 ± 2.1 |
76.8 ± 4.7* |
165.3 ± 7.9* |
|
|
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|
Arterial blood gases, mean arterial pressure, and Evans blue dye analysis of normal nonventilated mice and of mice placed on either room air or hyperoxia for 5 hours (n = 10/group). *P < 0.05 versus control, nonventilated mice. |
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|
Li et al. Critical Care 2007 11:R89 doi:10.1186/cc6101 |
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