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Characteristics and parameters of TK/TD relationships regarding the rate of glucose infusion versus insulin concentrations in six deliberate insulin intoxications |
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| Patient |
Sex/age (years) |
Diabetes |
Insulin type/dose |
Delay to initial therapy (hours) |
Lowest blood glucose level (mmol/l) |
Emax (g/h) |
EC50 (mU/l) |
Cmax (mIU/l) |
R2 |
T1/2 (hours) |
Outcome |
|
|
|||||||||||
| 1 |
Male/60 |
Type 1 |
Rapid-acting/500 IU |
2.0 |
0.8 |
17.5 |
667 |
1,853 |
0.98 |
3.5 |
Alive |
| 2 |
Female/40 |
Type 1 |
30% rapid-acting/70% slow-acting/120 IU |
0.8 |
0.8 |
36 |
35 |
151 |
0.91 |
4.0 |
Alive |
| 3 |
Female/52 |
Type 2 |
Slow-acting/1,500 IU |
2.6 |
2.0 |
119.9 |
42 |
704 |
0.71 |
11.7 |
Alive |
| 4 |
Female/45 |
Nondiabetic |
Rapid-acting/100 IU |
0.3 |
1.1 |
23.1 |
161 |
9,053 |
0.88 |
0.8 |
Alive |
| 5 |
Male/16 |
Nondiabetic |
Slow-acting/1,500 IU |
1.5 |
2.5 |
41.1 |
50 |
5,740 |
0.70 |
4.6 |
Alive |
| 6 |
Female/60 |
Nondiabetic |
Rapid-acting/1,200 IU |
1.0 |
1.7 |
14.6 |
12 |
197 |
0.79 |
1.5 |
Alive |
|
Cmax, maximal observed concentration; EC50, concentration associated with half-maximal effect; Emax, maximum possible measured glucose infusion rate; R2, correlation coefficient for the TK/TD model; T1/2, half-life; TK/TD, toxicokinetic/toxicodynamic. | |||||||||||
Mégarbane et al. Critical Care 2007 11:R115 doi:10.1186/cc6168 |
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