Table 1

Systemic hemodynamics and metabolic variables during infusion of vasopressin
Time
300 minutes
 360 minutes
 480 minutes
Heart rate (beats per minute)a,b




Group C
 126 ± 24
 131 ± 26
 136 ± 29

Group V
 125 ± 15
 90 ± 8c
 104 ± 14c

Group S
 120 ± 23
 135 ± 26d
 155 ± 29c

Group SV
 126 ± 10
 106 ± 21c
 117 ± 22
Mean arterial blood pressure (mm Hg)a,b




Group C
 80 ± 12
 80 ± 13
 77 ± 13

Group V
 80 ± 9
 97 ± 9c
 100 ± 11c

Group S
 68 ± 9
 67 ± 9
 67 ± 7

Group SV
 74 ± 9
 100 ± 22c
 95 ± 20c
Cardiac index (mL/kg per minute)a,b




Group C
 148 ± 31
 147 ± 33
 149 ± 34

Group V
 147 ± 27
 96 ± 13c
 118 ± 12d

Group S
 174 ± 22
 166 ± 20
 179 ± 14

Group SV
 168 ± 47
 107 ± 13c
 125 ± 27c
PAOP (mm Hg)a,e




Group C
 6 ± 1
 7 ± 1
 6 ± 1

Group V
 6 ± 1
 8 ± 1d
 8 ± 2c

Group S
 8 ± 1
 6 ± 1
 6 ± 2

Group SV
 6 ± 1
 6 ± 2
 6 ± 2
Arterial pH




Group C
 7.45 ± 0.03
 7.45 ± 0.03
 7.44 ± 0.04

Group V
 7.44 ± 0.02
 7.44 ± 0.04
 7.44 ± 0.05

Group S
 7.43 ± 0.02
 7.44 ± 0.02
 7.43 ± 0.02

Group SV
 7.43 ± 0.04
 7.43 ± 0.04
 7.43 ± 0.04
Arterial standard base excess (mmol/L)




Group C
 3.9 ± 1.4
 3.6 ± 1.5
 3.3 ± 1.8

Group V
 2.4 ± 1.6
 2.9 ± 1.9
 2.9 ± 2.2

Group S
 3.1 ± 0.9
 3.7 ± 0.5
 3.2 ± 0.9

Group SV
 2.2 ± 1.2
 3.0 ± 1.2
 2.7 ± 1.5
Arterial lactate concentration (mmol/L)




Group C
 0.99 ± 0.15
 0.96 ± 0.12
 0.95 ± 0.17

Group V
 0.98 ± 0.12
 1.10 ± 0.24
 1.11 ± 0.26d

Group S
 1.36 ± 0.48
 1.11 ± 0.31c
 1.10 ± 0.30c

Group SV
 1.46 ± 0.25
 1.25 ± 0.17c
 1.20 ± 0.16c
Arterial oxygen partial pressure (mm Hg)f




Group C
 162 ± 19
 156 ± 21
 152 ± 25

Group V
 161 ± 16
 143 ± 29d
 141 ± 21

Group S
 163 ± 17
 163 ± 16
 161 ± 19

Group SV
 165 ± 10
 157 ± 21
 160 ± 13
Mixed venous oxygen saturation (percentage)a,b,e




Group C
 66 ± 5
 65 ± 6
 66 ± 5

Group V
 64 ± 10
 42 ± 10c
 49 ± 11c

Group S
 59 ± 5
 59 ± 5
 61 ± 5

Group SV
 61 ± 6
 53 ± 7c
 58 ± 7
DO2I sys (mL/kg per minute)a,b




Group C
 18 ± 2.6
 18 ± 2.7
 19 ± 2.8

Group V
 16 ± 2.8
 9.4 ± 1.9c
 11 ± 1.8d

Group S
 17 ± 2.1
 18 ± 3.3
 20 ± 2.8

Group SV
 19 ± 5.5
 13 ± 2.2c
 15 ± 3.6
VO2I sys (mL/kg per minute)




Group C
 6.1 ± 0.8
 6.0 ± 1.1
 6.2 ± 1.1

Group V
 5.7 ± 0.7
 5.6 ± 1.2
 5.7 ± 1.1

Group S
 7.3 ± 1.3
 7.3 ± 1.5
 7.7 ± 0.5

Group SV
 7.5 ± 1.8
 6.0 ± 0.9d
 6.2 ± 1.1
Urinary output (mL/kg per hour)




Group C
 2.1 ± 2.4
 2.3 ± 2.4
 1.8 ± 2.2

Group V
 1.6 ± 0.8
 3.8 ± 2.2
 5.4 ± 3.9d

Group S
 1.4 ± 0.9
 1.9 ± 1.4
 0.9 ± 0.5

Group SV
 1.0 ± 0.5
 3.5 ± 3.2
 2.6 ± 2.0

In groups V and SV, a continuous infusion of vasopressin (0.06 IU/kg per hour) was started at t = 300 minutes. Groups C and S received intravenous crystalloids only.

ap < 0.05 time-group interaction groups V versus C: effect of vasopressin in control animals.

bp < 0.01 time-group interaction groups SV versus S: effect of vasopressin in septic animals.

cp < 0.01 compared to t = 300 minutes.

dp < 0.05 compared to t = 300 minutes.

ep < 0.01 Mann-Whitney test (area under curve): effect of vasopressin in non-septic versus septic animals.

fp < 0.05 time-group interaction groups SV versus S: effect of vasopressin in septic animals.

DO2I sys: systemic oxygen delivery index. Group C: non-septic control group. Group S: septic control group. Group SV: septic test group treated with vasopressin. Group V: non-septic vasopressin control group. PAOP: pulmonary artery occlusion pressure. VO2I sys: systemic oxygen consumption index.

Krejci et al. Critical Care 2007 11:R129   doi:10.1186/cc6197