Table 2

Regional blood flow and oxygen delivery during infusion of vasopressin
Time
300 minutes
 360 minutes
 480 minutes
Celiac trunk (mL/kg per minute)a,b




Group C
 11 ± 3
 12 ± 2
 12 ± 2

Group V
 17 ± 6
 23 ± 5c
 23 ± 5c

Group S
 19 ± 8
 17 ± 5
 16 ± 4

Group SV
 25 ± 17
 31 ± 18d
 30 ± 17d
Liver flow (mL/kg per minute)a,b,e




Group C
 36 ± 3
 35 ± 5
 33 ± 4

Group V
 38 ± 9
 31 ± 6c
 33 ± 5d

Group S
 45 ± 8
 37 ± 6c
 35 ± 5c

Group SV
 43 ± 7
 29 ± 6c
 31 ± 6d
DO2I PV (mL/kg per minute)a,b,e




Group C
 2.7 ± 0.4
 2.6 ± 0.5
 2.6 ± 0.4

Group V
 2.5 ± 0.6
 1.2 ± 0.2c
 1.4 ± 0.2c

Group S
 2.7 ± 0.5
 2.2 ± 0.5d
 2.1 ± 0.4c

Group SV
 3.1 ± 0.7
 1.3 ± 0.6c
 1.7 ± 0.4c
DO2I HA (mL/kg per minute)a,b




Group C
 0.3 ± 0.3
 0.4 ± 0.3
 0.4 ± 0.3

Group V
 0.5 ± 0.2
 0.8 ± 0.3
 0.8 ± 0.2

Group S
 0.6 ± 0.3
 0.6 ± 0.3
 0.6 ± 0.3

Group SV
 0.6 ± 0.3
 1.0 ± 0.7c
 1.0 ± 0.7c
DO2I liver (mL/kg per minute)a




Group C
 3.2 ± 0.4
 3 ± 0.6
 3.1 ± 0.5

Group V
 3.0 ± 0.7
 2.0 ± 0.5c
 2.2 ± 0.3c

Group S
 3.3 ± 0.6
 2.8 ± 0.6
 2.7 ± 0.6d

Group SV
 3.6 ± 0.8
 2.3 ± 0.9c
 2.6 ± 0.9c
Renal artery (mL/kg per minute)a,b




Group C
 8.7 ± 1.3
 9.3 ± 1.3
 9.1 ± 1.5

Group V
 8.9 ± 2.2
 7.6 ± 2.3d
 8.9 ± 2.7

Group S
 8.1 ± 3.0
 8.8 ± 3.5
 9.0 ± 4.0

Group SV
 6.2 ± 2.3
 5.4 ± 1.6
 7 ± 2.4
DO2I kidney (mL/kg per minute)a,e




Group C
 1.1 ± 0.2
 1.1 ± 0.3
 1.2 ± 0.3

Group V
 1.0 ± 0.2
 0.7 ± 0.2c
 0.9 ± 0.3

Group S
 0.7 ± 0.4
 0.8 ± 0.5
 0.9 ± 0.6c

Group SV
 0.7 ± 0.2
 0.6 ± 0.2
 0.8 ± 0.3d

A continuous infusion of vasopressin (0.06 IU/kg per hour) was started in groups V and SV at t = 300 minutes. Animals in groups C and S received intravenous saline only.

ap < 0.01 time-group interaction groups V versus C: effect of vasopressin in control animals.

bp < 0.01 time-group interaction groups SV versus S: effect of vasopressin in septic animals.

cp < 0.01 compared to t = 300 minutes.

dp < 0.05 compared to t = 300 minutes.

ep < 0.05 Mann-Whitney test (area under curve): effect of vasopressin in non-septic versus septic animals.

Celiac trunk: blood flow in the celiac trunk. DO2I HA: oxygen delivered by the hepatic artery. DO2I kidney: total oxygen delivered by the left renal artery. DO2I liver: total oxygen delivery to the liver. DO2I PV: oxygen delivered by the portal vein. Group C: non-septic control group. Group S: septic control group. Group SV: septic test group treated with vasopressin. Group V: non-septic vasopressin control group. Liver flow: total liver blood flow. Renal artery: blood flow in the left renal artery.

Krejci et al. Critical Care 2007 11:R129   doi:10.1186/cc6197